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- NCIT_C157537 IAO_0000115 "A fixed combination of elvitegravir, a human immunodeficiency virus type 1 (HIV-1) integrase strand transfer inhibitor (INSTI); cobicistat, a cytochrome P450 3A (CYP3A) inhibitor; emtricitabine, a nucleoside reverse transcriptase (RT) inhibitor (NRTI) analog of cytidine; and tenofovir alafenamide fumarate, the fumarate salt form of the lipophilic phosphonamidate prodrug of tenofovir, a NRTI analog of adenosine monophosphate, that is used to treat human immunodeficiency virus (HIV) infection. Upon oral administration, elvitegravir inhibits the activity of integrase, an HIV-1 coded enzyme that is necessary for viral replication. Inhibition of integrase prevents the integration of HIV-1 DNA into host genomic DNA. Cobicistat inhibits CYP3A, thereby limiting the oxidative metabolism of elvitegravir and increases its systemic exposure. Emtricitabine and tenofovir inhibit the activity of HIV RT by competing with natural deoxyribonucleosides for incorporation into the growing viral DNA chain resulting in early chain termination. This interferes with the generation of DNA copies of viral RNA, which is necessary for the synthesis of new virions." @default.
- NCIT_C157537 NCIT_NHC0 "C157537" @default.
- NCIT_C157537 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C157537 NCIT_P108 "Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Fumarate" @default.
- NCIT_C157537 NCIT_P207 "C4058850" @default.
- NCIT_C157537 normalizedInformationContent "100" @default.
- NCIT_C157537 referenceCount "1" @default.
- NCIT_C157537 hasExactSynonym "EVG/COBI/FTC/TAF" @default.
- NCIT_C157537 hasExactSynonym "Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Fumarate" @default.
- NCIT_C157537 hasExactSynonym "Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide" @default.
- NCIT_C157537 hasExactSynonym "Genvoya" @default.
- NCIT_C157537 type Class @default.
- NCIT_C157537 isDefinedBy ncit.owl @default.
- NCIT_C157537 label "Elvitegravir/Cobicistat/Emtricitabine/Tenofovir Alafenamide Fumarate" @default.
- NCIT_C157537 subClassOf NCIT_C157537 @default.
- NCIT_C157537 subClassOf NCIT_C1660 @default.
- NCIT_C157537 subClassOf NCIT_C1908 @default.
- NCIT_C157537 subClassOf NCIT_C1909 @default.
- NCIT_C157537 subClassOf NCIT_C254 @default.
- NCIT_C157537 subClassOf NCIT_C281 @default.