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- NCIT_C157543 IAO_0000115 "A fixed combination of abacavir sulfate, a nucleoside reverse transcriptase inhibitor (NRTI) analog of guanosine; dolutegravir, an integrase strand-transfer inhibitor (INSTI); and lamivudine, an NRTI analog of cytidine, that may be used to treat human immunodeficiency virus (HIV) infection. Upon oral administration, abacavir and lamivudine are phosphorylated into active metabolites that inhibit the HIV reverse transcriptase (RT) enzyme competitively and act as a chain terminator of DNA synthesis. This interferes with the generation of DNA copies of viral RNA, which is necessary for the synthesis of new virions. Dolutegravir binds to the active site of integrase, an HIV enzyme that catalyzes the transfer of viral genetic material into human chromosomes. This prevents integrase from binding to retroviral deoxyribonucleic acid (DNA), and blocks the strand transfer step, which is essential for the HIV replication cycle. This further prevents HIV-1 replication." @default.
- NCIT_C157543 NCIT_NHC0 "C157543" @default.
- NCIT_C157543 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C157543 NCIT_P108 "Abacavir/Dolutegravir/Lamivudine" @default.
- NCIT_C157543 NCIT_P207 "C3854896" @default.
- NCIT_C157543 normalizedInformationContent "100" @default.
- NCIT_C157543 referenceCount "1" @default.
- NCIT_C157543 hasExactSynonym "ABC/DTG/3TC" @default.
- NCIT_C157543 hasExactSynonym "Abacavir/Dolutegravir/Lamivudine" @default.
- NCIT_C157543 hasExactSynonym "Triumeq" @default.
- NCIT_C157543 type Class @default.
- NCIT_C157543 isDefinedBy ncit.owl @default.
- NCIT_C157543 label "Abacavir/Dolutegravir/Lamivudine" @default.
- NCIT_C157543 subClassOf NCIT_C157401 @default.
- NCIT_C157543 subClassOf NCIT_C157543 @default.
- NCIT_C157543 subClassOf NCIT_C1589 @default.
- NCIT_C157543 subClassOf NCIT_C1660 @default.
- NCIT_C157543 subClassOf NCIT_C1908 @default.
- NCIT_C157543 subClassOf NCIT_C1909 @default.
- NCIT_C157543 subClassOf NCIT_C254 @default.
- NCIT_C157543 subClassOf NCIT_C281 @default.
- NCIT_C157543 subClassOf NCIT_C471 @default.