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- NCIT_C157578 IAO_0000115 "A humanized, Fc-engineered bispecific monoclonal antibody directed against both the human negative immunoregulatory checkpoint receptor, programmed cell death protein 1 (PD-1; PCD-1; CD279), and inducible T-cell co-stimulator (ICOS; CD278), with potential immunomodulating and antineoplastic activities. Upon administration, izuralimab targets and binds to both PD-1 and ICOS expressed on certain T-cells, including tumor-infiltrating lymphocytes (TILs). This prevents the activation of PD-1 by its ligands, programmed cell death-1 ligand 1 (PD-L1) and PD-1 ligand 2 (PD-L2), and stimulates ICOS-mediated signaling, which promotes the activation of T-cells and enhances T-cell-mediated immune responses against tumor cells. Combined PD-1 blockade and ICOS stimulation may enhance T-cell activation and proliferation more than targeting each receptor individually. The engineered Fc domain increases the stability and half-life of the antibody." @default.
- NCIT_C157578 NCIT_A7 NCIT_C94697 @default.
- NCIT_C157578 NCIT_A7 NCIT_C94803 @default.
- NCIT_C157578 NCIT_NHC0 "C157578" @default.
- NCIT_C157578 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C157578 NCIT_P107 "Anti-PD1/ICOS Bispecific Monoclonal Antibody XmAb23104" @default.
- NCIT_C157578 NCIT_P108 "Izuralimab" @default.
- NCIT_C157578 NCIT_P208 "CL937279" @default.
- NCIT_C157578 NCIT_P210 "2329669-80-7" @default.
- NCIT_C157578 NCIT_P319 "9D2R4T39AY" @default.
- NCIT_C157578 NCIT_P322 "CTRP" @default.
- NCIT_C157578 NCIT_P322 "FDA" @default.
- NCIT_C157578 NCIT_P329 "796973" @default.
- NCIT_C157578 NCIT_P330 "796973" @default.
- NCIT_C157578 NCIT_P399 "796973" @default.
- NCIT_C157578 NCIT_R124 NCIT_C17710 @default.
- NCIT_C157578 NCIT_R124 NCIT_C17828 @default.
- NCIT_C157578 NCIT_R124 NCIT_C18219 @default.
- NCIT_C157578 NCIT_R124 NCIT_C19986 @default.
- NCIT_C157578 NCIT_R124 NCIT_C40474 @default.
- NCIT_C157578 normalizedInformationContent "100" @default.
- NCIT_C157578 referenceCount "1" @default.
- NCIT_C157578 hasExactSynonym "Anti-PD1/Anti-ICOS Bispecific Monoclonal Antibody XmAb23104" @default.
- NCIT_C157578 hasExactSynonym "Anti-PD1/ICOS Bispecific Monoclonal Antibody XmAb23104" @default.
- NCIT_C157578 hasExactSynonym "IZURALIMAB" @default.
- NCIT_C157578 hasExactSynonym "Izuralimab" @default.
- NCIT_C157578 hasExactSynonym "PD1 x ICOS Bispecific Monoclonal Antibody XmAb23104" @default.
- NCIT_C157578 hasExactSynonym "XmAb 23104" @default.
- NCIT_C157578 hasExactSynonym "XmAb-23104" @default.
- NCIT_C157578 hasExactSynonym "XmAb23104" @default.
- NCIT_C157578 inSubset NCIT_C116977 @default.
- NCIT_C157578 inSubset NCIT_C116978 @default.
- NCIT_C157578 inSubset NCIT_C128784 @default.
- NCIT_C157578 inSubset NCIT_C176424 @default.
- NCIT_C157578 inSubset NCIT_C63923 @default.
- NCIT_C157578 type Class @default.
- NCIT_C157578 isDefinedBy ncit.owl @default.
- NCIT_C157578 label "Izuralimab" @default.
- NCIT_C157578 subClassOf NCIT_C129821 @default.
- NCIT_C157578 subClassOf NCIT_C129822 @default.
- NCIT_C157578 subClassOf NCIT_C141144 @default.
- NCIT_C157578 subClassOf NCIT_C143250 @default.
- NCIT_C157578 subClassOf NCIT_C1454 @default.
- NCIT_C157578 subClassOf NCIT_C157578 @default.
- NCIT_C157578 subClassOf NCIT_C1908 @default.
- NCIT_C157578 subClassOf NCIT_C1909 @default.
- NCIT_C157578 subClassOf NCIT_C20401 @default.
- NCIT_C157578 subClassOf NCIT_C274 @default.
- NCIT_C157578 subClassOf NCIT_C28227 @default.
- NCIT_C157578 subClassOf NCIT_C307 @default.
- NCIT_C157578 subClassOf NCIT_C308 @default.