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- NCIT_C157632 IAO_0000115 "A bispecific monoclonal antibody directed against both the immunosuppressive ligand, programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), and cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, erfonrilimab targets and binds to both PD-L1 expressed on tumor cells and CTLA-4 expressed on T-cells. This prevents the binding of PD-L1 to its receptor, programmed cell death protein 1 (PD-1, CD279), and inhibits the PD-1 and CTLA-4-mediated downregulation of T-cell activation and proliferation. This restores immune function and activates a sustained cytotoxic T-lymphocyte (CTL)-mediated immune response against tumor cells. Both PD-L1, which is overexpressed in many human cancer cell types, and CTLA-4, an inhibitory T-cell receptor, play a role in the downregulation of the immune system and tumor evasion from host immunity." @default.
- NCIT_C157632 NCIT_A7 NCIT_C17489 @default.
- NCIT_C157632 NCIT_A7 NCIT_C96024 @default.
- NCIT_C157632 NCIT_NHC0 "C157632" @default.
- NCIT_C157632 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C157632 NCIT_P108 "Erfonrilimab" @default.
- NCIT_C157632 NCIT_P208 "CL937174" @default.
- NCIT_C157632 NCIT_P210 "2367013-69-0" @default.
- NCIT_C157632 NCIT_P319 "9NP50O6YSA" @default.
- NCIT_C157632 NCIT_P322 "FDA" @default.
- NCIT_C157632 NCIT_P329 "796892" @default.
- NCIT_C157632 NCIT_P330 "796892" @default.
- NCIT_C157632 NCIT_P399 "796892" @default.
- NCIT_C157632 NCIT_R124 NCIT_C17710 @default.
- NCIT_C157632 NCIT_R124 NCIT_C17828 @default.
- NCIT_C157632 NCIT_R124 NCIT_C18219 @default.
- NCIT_C157632 NCIT_R124 NCIT_C19986 @default.
- NCIT_C157632 NCIT_R124 NCIT_C40474 @default.
- NCIT_C157632 normalizedInformationContent "100" @default.
- NCIT_C157632 referenceCount "1" @default.
- NCIT_C157632 hasExactSynonym "Anti-PD-L1 x CTLA-4 Bispecific Antibody KN046" @default.
- NCIT_C157632 hasExactSynonym "Anti-PD-L1/Anti-CTLA-4 Bispecific Antibody KN046" @default.
- NCIT_C157632 hasExactSynonym "Anti-PD-L1/CTLA-4 Bispecific Antibody KN046" @default.
- NCIT_C157632 hasExactSynonym "ERFONRILIMAB" @default.
- NCIT_C157632 hasExactSynonym "Erfonrilimab" @default.
- NCIT_C157632 hasExactSynonym "KN 046" @default.
- NCIT_C157632 hasExactSynonym "KN-046" @default.
- NCIT_C157632 hasExactSynonym "KN046" @default.
- NCIT_C157632 inSubset NCIT_C128784 @default.
- NCIT_C157632 inSubset NCIT_C176424 @default.
- NCIT_C157632 inSubset NCIT_C63923 @default.
- NCIT_C157632 type Class @default.
- NCIT_C157632 isDefinedBy ncit.owl @default.
- NCIT_C157632 label "Erfonrilimab" @default.
- NCIT_C157632 subClassOf NCIT_C128036 @default.
- NCIT_C157632 subClassOf NCIT_C129821 @default.
- NCIT_C157632 subClassOf NCIT_C129822 @default.
- NCIT_C157632 subClassOf NCIT_C141144 @default.
- NCIT_C157632 subClassOf NCIT_C143250 @default.
- NCIT_C157632 subClassOf NCIT_C1454 @default.
- NCIT_C157632 subClassOf NCIT_C157632 @default.
- NCIT_C157632 subClassOf NCIT_C163758 @default.
- NCIT_C157632 subClassOf NCIT_C1908 @default.
- NCIT_C157632 subClassOf NCIT_C1909 @default.
- NCIT_C157632 subClassOf NCIT_C191738 @default.
- NCIT_C157632 subClassOf NCIT_C20401 @default.
- NCIT_C157632 subClassOf NCIT_C274 @default.
- NCIT_C157632 subClassOf NCIT_C28227 @default.
- NCIT_C157632 subClassOf NCIT_C307 @default.
- NCIT_C157632 subClassOf NCIT_C308 @default.