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- NCIT_C1577 IAO_0000115 "The dihydrochloride salt of nolatrexed, a water-soluble lipophilic quinazoline folate analog with antineoplastic activity. Nolatrexed occupies the folate binding site of thymidylate synthase, resulting in inhibition of thymidylate synthase activity and thymine nucleotide synthesis with subsequent inhibition of DNA replication, DNA damage, S-phase cell cycle arrest, and caspase-dependent apoptosis. This agent also exhibits radiosensitizing activity." @default.
- NCIT_C1577 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1577 NCIT_A6 NCIT_C143088 @default.
- NCIT_C1577 NCIT_NHC0 "C1577" @default.
- NCIT_C1577 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1577 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1577 NCIT_P108 "Nolatrexed Dihydrochloride" @default.
- NCIT_C1577 NCIT_P207 "C0796399" @default.
- NCIT_C1577 NCIT_P210 "152946-68-4" @default.
- NCIT_C1577 NCIT_P302 "Hepatocellular carcinoma" @default.
- NCIT_C1577 NCIT_P319 "1XA69O733O" @default.
- NCIT_C1577 NCIT_P322 "FDA" @default.
- NCIT_C1577 NCIT_P322 "GDC" @default.
- NCIT_C1577 NCIT_P325 "A substance that is being studied in the treatment of liver cancer. It belongs to the family of drugs called thymidylate synthase inhibitors." @default.
- NCIT_C1577 NCIT_P329 "42223" @default.
- NCIT_C1577 NCIT_P330 "42223" @default.
- NCIT_C1577 NCIT_P350 "C14H12N4OS.2ClH" @default.
- NCIT_C1577 NCIT_P366 "Nolatrexed" @default.
- NCIT_C1577 NCIT_P375 "Nolatrexed Dihydrochloride" @default.
- NCIT_C1577 NCIT_P399 "42223" @default.
- NCIT_C1577 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C1577 referenceCount "3" @default.
- NCIT_C1577 hasExactSynonym "3,4-Dihydro-2-amino-6-methyl-4-oxy-5-(4-pyridylthio)-quinazoline Dihydrochloride" @default.
- NCIT_C1577 hasExactSynonym "AG-337" @default.
- NCIT_C1577 hasExactSynonym "AG337" @default.
- NCIT_C1577 hasExactSynonym "NOLATREXED DIHYDROCHLORIDE" @default.
- NCIT_C1577 hasExactSynonym "Nolatrexed Dihydrochloride" @default.
- NCIT_C1577 hasExactSynonym "Nolatrexed Hydrochloride" @default.
- NCIT_C1577 hasExactSynonym "Thymitaq" @default.
- NCIT_C1577 hasExactSynonym "nolatrexed" @default.
- NCIT_C1577 inSubset NCIT_C128784 @default.
- NCIT_C1577 inSubset NCIT_C157711 @default.
- NCIT_C1577 inSubset NCIT_C157712 @default.
- NCIT_C1577 inSubset NCIT_C176424 @default.
- NCIT_C1577 inSubset NCIT_C177537 @default.
- NCIT_C1577 inSubset NCIT_C63923 @default.
- NCIT_C1577 type Class @default.
- NCIT_C1577 isDefinedBy ncit.owl @default.
- NCIT_C1577 label "Nolatrexed Dihydrochloride" @default.
- NCIT_C1577 subClassOf NCIT_C1577 @default.
- NCIT_C1577 subClassOf NCIT_C186664 @default.
- NCIT_C1577 subClassOf NCIT_C1908 @default.
- NCIT_C1577 subClassOf NCIT_C1909 @default.
- NCIT_C1577 subClassOf NCIT_C2021 @default.
- NCIT_C1577 subClassOf NCIT_C272 @default.
- NCIT_C1577 subClassOf NCIT_C274 @default.
- NCIT_C1577 subClassOf NCIT_C471 @default.
- NCIT_C1577 subClassOf NCIT_C511 @default.