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- NCIT_C157710 IAO_0000115 "A recombinant, replicating oncolytic vesicular stomatitis virus (VSV) carrying the human interferon-beta (IFN-b) gene and the tyrosinase related protein 1 (TYRP1) gene, with potential immunomodulating and antineoplastic activities. Upon intratumoral and intravenous administration, recombinant VSV-expressing IFN-b/TYRP1 preferentially replicates in tumor cells. Due to defective IFN-b-mediated innate antiviral host defense mechanisms in tumor cells, VSV is able to replicate in these cells without interference. This induces VSV-mediated cytolytic activity towards the tumor cells. By expressing human IFN-b, an IFN-b-mediated antiviral immune response in surrounding normal cells is activated which protects normal cells against virus replication and the associated VSV-mediated cell lysis. Also, the IFN-b produced by VSV may activate an immune response in surrounding normal cells, involving the activation of cytotoxic T-lymphocytes (CTL), dendritic cells (DCs) and natural killer (NK) cells. This induces an anti-tumor immune response against the tumor cells. In addition, the expression of TYRP1 further activates the immune system to induce a CTL-mediated immune response against the TYRP1-expressing tumor cells, thereby further killing TYRP1-expressing tumor cells. VSV, a single-stranded RNA virus belonging to the genus Vesiculovirus of the family Rhabdoviridae, is relatively nonpathogenic to healthy humans but is able to rapidly replicate in and induce apoptosis of tumor cells. TYRP1, a tumor-associated antigen (TAA), is primarily expressed in melanocytes and melanomas." @default.
- NCIT_C157710 NCIT_A7 NCIT_C18271 @default.
- NCIT_C157710 NCIT_NHC0 "C157710" @default.
- NCIT_C157710 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C157710 NCIT_P106 "Virus" @default.
- NCIT_C157710 NCIT_P107 "Recombinant Vesicular Stomatitis Virus-expressing Interferon-beta and Tyrosinase Related Protein 1" @default.
- NCIT_C157710 NCIT_P108 "Recombinant Vesicular Stomatitis Virus-expressing Interferon-beta and Tyrosinase Related Protein 1" @default.
- NCIT_C157710 NCIT_P208 "CL937337" @default.
- NCIT_C157710 NCIT_P322 "CTRP" @default.
- NCIT_C157710 NCIT_P329 "797080" @default.
- NCIT_C157710 NCIT_P330 "797080" @default.
- NCIT_C157710 NCIT_P399 "797080" @default.
- NCIT_C157710 normalizedInformationContent "100" @default.
- NCIT_C157710 referenceCount "1" @default.
- NCIT_C157710 hasExactSynonym "Recombinant VSV-IFNbetaTYRP1" @default.
- NCIT_C157710 hasExactSynonym "Recombinant VSV-expressing IFN-b and TYRP1" @default.
- NCIT_C157710 hasExactSynonym "Recombinant Vesicular Stomatitis Virus-expressing Interferon-beta and Tyrosinase Related Protein 1" @default.
- NCIT_C157710 hasExactSynonym "VSV-IFN-b/TYRP1" @default.
- NCIT_C157710 hasExactSynonym "VSV-IFNbetaTYRP1" @default.
- NCIT_C157710 inSubset NCIT_C116977 @default.
- NCIT_C157710 inSubset NCIT_C116978 @default.
- NCIT_C157710 inSubset NCIT_C128784 @default.
- NCIT_C157710 inSubset NCIT_C176424 @default.
- NCIT_C157710 type Class @default.
- NCIT_C157710 isDefinedBy ncit.owl @default.
- NCIT_C157710 label "Recombinant Vesicular Stomatitis Virus-expressing Interferon-beta and Tyrosinase Related Protein 1" @default.
- NCIT_C157710 subClassOf NCIT_C129821 @default.
- NCIT_C157710 subClassOf NCIT_C157710 @default.
- NCIT_C157710 subClassOf NCIT_C1908 @default.
- NCIT_C157710 subClassOf NCIT_C1909 @default.
- NCIT_C157710 subClassOf NCIT_C274 @default.
- NCIT_C157710 subClassOf NCIT_C307 @default.
- NCIT_C157710 subClassOf NCIT_C717 @default.