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- NCIT_C157771 IAO_0000115 "A spherical nucleic acid (SN)-based agonist of toll-like receptor 9 (TLR9), with potential immunostimulating activity. Upon administration, cavrotolimod targets and is able to enter various immune cells, including monocytes/macrophages, plasmacytoid dendritic cells (pDCs), natural killer (NK) cells and B cells, through endocytosis. Within the endosome, it binds to and activates TLR9. TLR9 activation induces immune signaling pathways and activates various immune cells, including B-cells, pDCs, NKs, and induces both the production of T-helper 1 cells (Th1) and a Th1-mediated immune response as well as a cytotoxic T-lymphocyte (CTL)-based immune response against tumor cells. This results in an inhibition of tumor cell proliferation. TLR9 is a member of the TLR family, which plays a fundamental role in pathogen recognition and activation of innate and adaptive immune responses. The SNA is a dense, radial arrangement of nucleic acids (DNA) on the surface of liposomal nanoparticles, providing a 3D-construct, that has a high cellular uptake and an increased presentation of the DNA for TLR9 agonism. It also protects against breakdown by nucleases and increases the half-life of the construct compared to linear oligonucleotides that are not in SNA format." @default.
- NCIT_C157771 NCIT_A32 NCIT_C1909 @default.
- NCIT_C157771 NCIT_A7 NCIT_C96048 @default.
- NCIT_C157771 NCIT_NHC0 "C157771" @default.
- NCIT_C157771 NCIT_P106 "Nucleic Acid, Nucleoside, or Nucleotide" @default.
- NCIT_C157771 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C157771 NCIT_P107 "Cavrotolimod" @default.
- NCIT_C157771 NCIT_P108 "Cavrotolimod" @default.
- NCIT_C157771 NCIT_P208 "CL937384" @default.
- NCIT_C157771 NCIT_P210 "2378664-12-9" @default.
- NCIT_C157771 NCIT_P319 "2Z5JOV1PPN" @default.
- NCIT_C157771 NCIT_P322 "CTRP" @default.
- NCIT_C157771 NCIT_P322 "FDA" @default.
- NCIT_C157771 NCIT_P322 "GDC" @default.
- NCIT_C157771 NCIT_P329 "797159" @default.
- NCIT_C157771 NCIT_P330 "797159" @default.
- NCIT_C157771 NCIT_P375 "TLR9 Agonist AST-008" @default.
- NCIT_C157771 NCIT_P399 "797159" @default.
- NCIT_C157771 normalizedInformationContent "100" @default.
- NCIT_C157771 referenceCount "1" @default.
- NCIT_C157771 hasExactSynonym "AST 008" @default.
- NCIT_C157771 hasExactSynonym "AST-008" @default.
- NCIT_C157771 hasExactSynonym "AST008" @default.
- NCIT_C157771 hasExactSynonym "CAVROTOLIMOD" @default.
- NCIT_C157771 hasExactSynonym "Cavrotolimod" @default.
- NCIT_C157771 hasExactSynonym "SNA AST-008" @default.
- NCIT_C157771 hasExactSynonym "TLR9 Agonist AST-008" @default.
- NCIT_C157771 hasExactSynonym "Toll-like Receptor 9 Activator AST-008" @default.
- NCIT_C157771 inSubset NCIT_C116977 @default.
- NCIT_C157771 inSubset NCIT_C116978 @default.
- NCIT_C157771 inSubset NCIT_C157711 @default.
- NCIT_C157771 inSubset NCIT_C157712 @default.
- NCIT_C157771 inSubset NCIT_C176424 @default.
- NCIT_C157771 inSubset NCIT_C177537 @default.
- NCIT_C157771 inSubset NCIT_C63923 @default.
- NCIT_C157771 type Class @default.
- NCIT_C157771 isDefinedBy ncit.owl @default.
- NCIT_C157771 label "Cavrotolimod" @default.
- NCIT_C157771 subClassOf NCIT_C157771 @default.
- NCIT_C157771 subClassOf NCIT_C177174 @default.
- NCIT_C157771 subClassOf NCIT_C177175 @default.
- NCIT_C157771 subClassOf NCIT_C1908 @default.
- NCIT_C157771 subClassOf NCIT_C1909 @default.
- NCIT_C157771 subClassOf NCIT_C2139 @default.
- NCIT_C157771 subClassOf NCIT_C308 @default.