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- NCIT_C157777 IAO_0000115 "A cancer vaccine comprised of a genetically engineered, replication-deficient adenovirus encoding inactive, mutant forms of the human papillomavirus (HPV) transforming proteins E6 and E7, with potential immunostimulating and antineoplastic activities. Upon administration of adenovirus expressing mutant HPV E6/E7, the adenovirus infects and expresses the E6 and E7 proteins. The expressed E6 and E7 proteins stimulate the host immune system to mount a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing HPV E6 and E7, thereby inducing tumor cell lysis. Oncoproteins E6 and E7 play a key role in the development of cervical intraepithelial neoplasia (CIN) and cervical carcinoma." @default.
- NCIT_C157777 NCIT_A7 NCIT_C19170 @default.
- NCIT_C157777 NCIT_A7 NCIT_C19171 @default.
- NCIT_C157777 NCIT_NHC0 "C157777" @default.
- NCIT_C157777 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C157777 NCIT_P107 "Adenovirus Expressing Mutant HPV E6/E7" @default.
- NCIT_C157777 NCIT_P108 "Adenovirus Expressing Mutant HPV E6/E7" @default.
- NCIT_C157777 NCIT_P208 "CL937425" @default.
- NCIT_C157777 NCIT_P322 "CTRP" @default.
- NCIT_C157777 NCIT_P329 "797169" @default.
- NCIT_C157777 NCIT_P330 "797169" @default.
- NCIT_C157777 NCIT_P399 "797169" @default.
- NCIT_C157777 NCIT_R125 NCIT_C16298 @default.
- NCIT_C157777 NCIT_R125 NCIT_C17709 @default.
- NCIT_C157777 NCIT_R125 NCIT_C17828 @default.
- NCIT_C157777 NCIT_R125 NCIT_C17930 @default.
- NCIT_C157777 NCIT_R125 NCIT_C17937 @default.
- NCIT_C157777 NCIT_R125 NCIT_C18839 @default.
- NCIT_C157777 NCIT_R125 NCIT_C19053 @default.
- NCIT_C157777 NCIT_R125 NCIT_C21124 @default.
- NCIT_C157777 NCIT_R125 NCIT_C26280 @default.
- NCIT_C157777 NCIT_R125 NCIT_C40833 @default.
- NCIT_C157777 normalizedInformationContent "100" @default.
- NCIT_C157777 referenceCount "1" @default.
- NCIT_C157777 hasExactSynonym "Ad-E6/E7" @default.
- NCIT_C157777 hasExactSynonym "Ad-E6E7" @default.
- NCIT_C157777 hasExactSynonym "Adenoviral-HPV E6E7 Vaccine" @default.
- NCIT_C157777 hasExactSynonym "Adenoviral-expressing Mutant HPV E6/E7" @default.
- NCIT_C157777 hasExactSynonym "Adenovirus Expressing Mutant HPV E6/E7" @default.
- NCIT_C157777 hasExactSynonym "Adenovirus Vaccine Expressing Mutant HPV E6 and E7" @default.
- NCIT_C157777 inSubset NCIT_C116977 @default.
- NCIT_C157777 inSubset NCIT_C116978 @default.
- NCIT_C157777 inSubset NCIT_C128784 @default.
- NCIT_C157777 inSubset NCIT_C176424 @default.
- NCIT_C157777 type Class @default.
- NCIT_C157777 isDefinedBy ncit.owl @default.
- NCIT_C157777 label "Adenovirus Expressing Mutant HPV E6/E7" @default.
- NCIT_C157777 subClassOf B1a27e2a06586b074d9164a6473680966 @default.
- NCIT_C157777 subClassOf B2335fb6b8207c01ada1f5d3ccbb7bc17 @default.
- NCIT_C157777 subClassOf Bd111d451a9fe63f3432c8ca9f570a56d @default.
- NCIT_C157777 subClassOf Bd968f7a881d01e71a6782e197f5d1b24 @default.
- NCIT_C157777 subClassOf NCIT_C1572 @default.
- NCIT_C157777 subClassOf NCIT_C157777 @default.
- NCIT_C157777 subClassOf NCIT_C1908 @default.
- NCIT_C157777 subClassOf NCIT_C1909 @default.
- NCIT_C157777 subClassOf NCIT_C1962 @default.
- NCIT_C157777 subClassOf NCIT_C307 @default.
- NCIT_C157777 subClassOf NCIT_C308 @default.
- NCIT_C157777 subClassOf NCIT_C49146 @default.
- NCIT_C157777 subClassOf NCIT_C923 @default.
- NCIT_C157777 subClassOf NCIT_C96404 @default.