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- NCIT_C1578 IAO_0000115 "A humanized bivalent antibody directed against both cytotoxic effector cells expressing Fc gamma receptor type I (Fc gammaRI, or CD64) and HER2/neu-overexpressing tumor cells with potential antineoplastic activity. Bispecific antibody MDX-H210 was constructed by chemically linking Fab' fragments of the anti-HER2/neu-specific monoclonal antibody 520C9 and the Fab' fragments of the anti-Fc gammaRI-specific monoclonal antibody H22. This agent selectively binds to both HER2/neu-expressing tumor cells and Fc gammaRI-expressing cytotoxic effector cells, which may trigger antibody-dependent cell-mediated cytotoxicity (ADCC) and cell lysis of HER2/neu-expressing tumor cells. While HER2/neu is overexpressed in a variety of epithelial malignancies, expression of Fc gammaRI is primarily found in cytotoxic immune cells, including monocytes, macrophages, and cytokine-activated polymorphonuclear (PMN) cells." @default.
- NCIT_C1578 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1578 NCIT_NHC0 "C1578" @default.
- NCIT_C1578 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C1578 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1578 NCIT_P108 "Bispecific Antibody MDX-H210" @default.
- NCIT_C1578 NCIT_P207 "C0281736" @default.
- NCIT_C1578 NCIT_P322 "GDC" @default.
- NCIT_C1578 NCIT_P329 "42227" @default.
- NCIT_C1578 NCIT_P330 "42227" @default.
- NCIT_C1578 NCIT_P366 "Bispecific_Antibody_520C9XH22" @default.
- NCIT_C1578 NCIT_P375 "Bispecific Antibody MDX-H210" @default.
- NCIT_C1578 NCIT_P399 "42227" @default.
- NCIT_C1578 normalizedInformationContent "92.730304365937428" @default.
- NCIT_C1578 referenceCount "3" @default.
- NCIT_C1578 hasExactSynonym "520C9x22 Bispecific Antibody" @default.
- NCIT_C1578 hasExactSynonym "520C9xH22 Bispecific Antibody" @default.
- NCIT_C1578 hasExactSynonym "Antibody, Bispecific 520C9xH22" @default.
- NCIT_C1578 hasExactSynonym "Bispecific Antibody 520C9 x H22" @default.
- NCIT_C1578 hasExactSynonym "Bispecific Antibody MDX-H210" @default.
- NCIT_C1578 hasExactSynonym "Bispecific Antibody MDXH210" @default.
- NCIT_C1578 hasExactSynonym "BsAb 520C9x22" @default.
- NCIT_C1578 hasExactSynonym "BsAb 520C9xH22" @default.
- NCIT_C1578 hasExactSynonym "MDX-210" @default.
- NCIT_C1578 hasExactSynonym "MDX-H210" @default.
- NCIT_C1578 inSubset NCIT_C128784 @default.
- NCIT_C1578 inSubset NCIT_C157711 @default.
- NCIT_C1578 inSubset NCIT_C157712 @default.
- NCIT_C1578 inSubset NCIT_C176424 @default.
- NCIT_C1578 inSubset NCIT_C177537 @default.
- NCIT_C1578 type Class @default.
- NCIT_C1578 isDefinedBy ncit.owl @default.
- NCIT_C1578 label "Bispecific Antibody MDX-H210" @default.
- NCIT_C1578 subClassOf NCIT_C1454 @default.
- NCIT_C1578 subClassOf NCIT_C1578 @default.
- NCIT_C1578 subClassOf NCIT_C1908 @default.
- NCIT_C1578 subClassOf NCIT_C1909 @default.
- NCIT_C1578 subClassOf NCIT_C307 @default.
- NCIT_C1578 subClassOf NCIT_C308 @default.