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- NCIT_C1579 IAO_0000115 "The hydrochloride form of eflornithine, a difluoromethylated ornithine compound with antineoplastic activity. Eflornithine irreversibly inhibits ornithine decarboxylase, an enzyme required for polyamine biosynthesis, thereby inhibiting the formation and proliferation of tumor cells. Polyamines are involved in nucleosome oligomerization and DNA conformation, creating a chromatin environment that stimulates neoplastic transformation of cells. (NCI04)" @default.
- NCIT_C1579 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1579 NCIT_A6 NCIT_C226 @default.
- NCIT_C1579 NCIT_A7 NCIT_C38931 @default.
- NCIT_C1579 NCIT_NHC0 "C1579" @default.
- NCIT_C1579 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C1579 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1579 NCIT_P107 "Eflornithine Hydrochloride" @default.
- NCIT_C1579 NCIT_P108 "Eflornithine Hydrochloride" @default.
- NCIT_C1579 NCIT_P175 "270295" @default.
- NCIT_C1579 NCIT_P175 "337250" @default.
- NCIT_C1579 NCIT_P207 "C0282042" @default.
- NCIT_C1579 NCIT_P210 "96020-91-6" @default.
- NCIT_C1579 NCIT_P319 "4NH22NDW9H" @default.
- NCIT_C1579 NCIT_P322 "CTRP" @default.
- NCIT_C1579 NCIT_P322 "FDA" @default.
- NCIT_C1579 NCIT_P322 "GDC" @default.
- NCIT_C1579 NCIT_P329 "39754" @default.
- NCIT_C1579 NCIT_P330 "39754" @default.
- NCIT_C1579 NCIT_P350 "C6H12F2N2O2.HCl.H2O" @default.
- NCIT_C1579 NCIT_P366 "Eflornithine_Hydrochloride" @default.
- NCIT_C1579 NCIT_P375 "Eflornithine Hydrochloride" @default.
- NCIT_C1579 NCIT_P399 "39754" @default.
- NCIT_C1579 normalizedInformationContent "100" @default.
- NCIT_C1579 referenceCount "1" @default.
- NCIT_C1579 hasExactSynonym "2-(Difluoromethyl)-dl-ornithine Hydrochloride, Monohydrate" @default.
- NCIT_C1579 hasExactSynonym "2-Difluoromethyl-dl-ornithine, Monohydrochloride, Monohydrate" @default.
- NCIT_C1579 hasExactSynonym "EFLORNITHINE HYDROCHLORIDE" @default.
- NCIT_C1579 hasExactSynonym "Eflornithine Hydrochloride" @default.
- NCIT_C1579 hasExactSynonym "Eflornithine hydrochloride" @default.
- NCIT_C1579 hasExactSynonym "Eflornithine.HCl" @default.
- NCIT_C1579 hasExactSynonym "MDL 71782" @default.
- NCIT_C1579 hasExactSynonym "Ornidyl" @default.
- NCIT_C1579 hasExactSynonym "RMI-71782" @default.
- NCIT_C1579 hasExactSynonym "Vaniqa" @default.
- NCIT_C1579 hasExactSynonym "alpha-Difluoromethylornithine hydrochloride" @default.
- NCIT_C1579 inSubset NCIT_C116977 @default.
- NCIT_C1579 inSubset NCIT_C116978 @default.
- NCIT_C1579 inSubset NCIT_C128784 @default.
- NCIT_C1579 inSubset NCIT_C157711 @default.
- NCIT_C1579 inSubset NCIT_C157712 @default.
- NCIT_C1579 inSubset NCIT_C176424 @default.
- NCIT_C1579 inSubset NCIT_C177537 @default.
- NCIT_C1579 inSubset NCIT_C63923 @default.
- NCIT_C1579 type Class @default.
- NCIT_C1579 isDefinedBy ncit.owl @default.
- NCIT_C1579 label "Eflornithine Hydrochloride" @default.
- NCIT_C1579 subClassOf NCIT_C129824 @default.
- NCIT_C1579 subClassOf NCIT_C1579 @default.
- NCIT_C1579 subClassOf NCIT_C1908 @default.
- NCIT_C1579 subClassOf NCIT_C1909 @default.
- NCIT_C1579 subClassOf NCIT_C2076 @default.
- NCIT_C1579 subClassOf NCIT_C2088 @default.
- NCIT_C1579 subClassOf NCIT_C2189 @default.
- NCIT_C1579 subClassOf NCIT_C274 @default.
- NCIT_C1579 subClassOf NCIT_C471 @default.