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- NCIT_C158044 IAO_0000115 "A radioconjucate consisting of CTT1403, a phosphoramidate-based irreversible inhibitor of human prostate-specific membrane antigen with an albumin binding moiety, connected via click chemistry to lutetium Lu 177-dodecanetetraacetic acid-azide (177Lu-DOTA-N3), with potential antineoplastic activity. Upon administration, lutetium Lu 177-DOTA-N3-CTT1403 targets and binds to PSMA expressed on tumor cells via its CTT1403 moiety, and upon internalization, delivers cytotoxic beta radiation directly to PSMA-expressing tumor cells. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on most prostate tumor cells. The albumin binding motif extends circulation half-life thereby improving tumor cell uptake of the radioconjugate." @default.
- NCIT_C158044 NCIT_A32 NCIT_C1909 @default.
- NCIT_C158044 NCIT_A7 NCIT_C17796 @default.
- NCIT_C158044 NCIT_NHC0 "C158044" @default.
- NCIT_C158044 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C158044 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C158044 NCIT_P107 "Lutetium Lu 177 DOTA-N3-CTT1403" @default.
- NCIT_C158044 NCIT_P108 "Lutetium Lu 177 DOTA-N3-CTT1403" @default.
- NCIT_C158044 NCIT_P208 "CL937593" @default.
- NCIT_C158044 NCIT_P322 "CTRP" @default.
- NCIT_C158044 NCIT_P322 "GDC" @default.
- NCIT_C158044 NCIT_P329 "797172" @default.
- NCIT_C158044 NCIT_P330 "797172" @default.
- NCIT_C158044 NCIT_P375 "Lutetium Lu 177 DOTA-N3-CTT1403" @default.
- NCIT_C158044 NCIT_P399 "797172" @default.
- NCIT_C158044 normalizedInformationContent "100" @default.
- NCIT_C158044 referenceCount "1" @default.
- NCIT_C158044 hasExactSynonym "177Lu-DOTA-N3-CTT1403" @default.
- NCIT_C158044 hasExactSynonym "177Lu-DOTA-azide-CTT1403" @default.
- NCIT_C158044 hasExactSynonym "Lutetium Lu 177 DOTA-N3-CTT1403" @default.
- NCIT_C158044 hasExactSynonym "Lutetium Lu 177 DOTA-azide-CTT1403" @default.
- NCIT_C158044 inSubset NCIT_C116977 @default.
- NCIT_C158044 inSubset NCIT_C116978 @default.
- NCIT_C158044 inSubset NCIT_C128784 @default.
- NCIT_C158044 inSubset NCIT_C157711 @default.
- NCIT_C158044 inSubset NCIT_C157712 @default.
- NCIT_C158044 inSubset NCIT_C176424 @default.
- NCIT_C158044 inSubset NCIT_C177537 @default.
- NCIT_C158044 type Class @default.
- NCIT_C158044 isDefinedBy ncit.owl @default.
- NCIT_C158044 label "Lutetium Lu 177 DOTA-N3-CTT1403" @default.
- NCIT_C158044 subClassOf NCIT_C129819 @default.
- NCIT_C158044 subClassOf NCIT_C1446 @default.
- NCIT_C158044 subClassOf NCIT_C1511 @default.
- NCIT_C158044 subClassOf NCIT_C1512 @default.
- NCIT_C158044 subClassOf NCIT_C158044 @default.
- NCIT_C158044 subClassOf NCIT_C1908 @default.
- NCIT_C158044 subClassOf NCIT_C1909 @default.
- NCIT_C158044 subClassOf NCIT_C2124 @default.
- NCIT_C158044 subClassOf NCIT_C274 @default.
- NCIT_C158044 subClassOf NCIT_C307 @default.
- NCIT_C158044 subClassOf NCIT_C308 @default.