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- NCIT_C158060 IAO_0000115 "A ready-to-use combination of trastuzumab, a recombinant humanized monoclonal antibody directed against the human epidermal growth factor receptor 2 (HER2; receptor tyrosine-protein kinase erbB-2), and hyaluronidase-oysk, a recombinant human hyaluronidase PH20 (rHuPH20), that may be used for the treatment of HER2-overexpressing breast cancers. Upon subcutaneous administration, hyaluronidase-oysk temporarily breaks down the hyaluronan barrier, which decreases viscosity of, and allows trastuzumab to spread rapidly through the interstitial space. This improves access to lymphatic and capillary vessels and facilitates the absorption of trastuzumab into the bloodstream. Trastuzumab binds to the extracellular ligand-binding domain of HER2 and mediates the activation of an antibody-dependent cell-mediated cytotoxicity (ADCC) against HER2-expressing tumor cells. HER2 is overexpressed in many adenocarcinomas, particularly breast adenocarcinomas." @default.
- NCIT_C158060 NCIT_A32 NCIT_C1909 @default.
- NCIT_C158060 NCIT_NHC0 "C158060" @default.
- NCIT_C158060 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C158060 NCIT_P107 "Trastuzumab/Hyaluronidase-oysk" @default.
- NCIT_C158060 NCIT_P108 "Trastuzumab/Hyaluronidase-oysk" @default.
- NCIT_C158060 NCIT_P208 "CL937577" @default.
- NCIT_C158060 NCIT_P302 "HER2 overexpressing breast cancer" @default.
- NCIT_C158060 NCIT_P322 "CTRP" @default.
- NCIT_C158060 NCIT_P322 "GDC" @default.
- NCIT_C158060 NCIT_P329 "797111" @default.
- NCIT_C158060 NCIT_P330 "797111" @default.
- NCIT_C158060 NCIT_P375 "Trastuzumab/Hyaluronidase-oysk" @default.
- NCIT_C158060 NCIT_P399 "797111" @default.
- NCIT_C158060 NCIT_R124 NCIT_C17710 @default.
- NCIT_C158060 NCIT_R124 NCIT_C17828 @default.
- NCIT_C158060 NCIT_R124 NCIT_C18219 @default.
- NCIT_C158060 NCIT_R124 NCIT_C19986 @default.
- NCIT_C158060 NCIT_R124 NCIT_C40474 @default.
- NCIT_C158060 normalizedInformationContent "95.413332725061409" @default.
- NCIT_C158060 referenceCount "2" @default.
- NCIT_C158060 hasExactSynonym "Herceptin Hylecta" @default.
- NCIT_C158060 hasExactSynonym "Trastuzumab and Hyaluronidase" @default.
- NCIT_C158060 hasExactSynonym "Trastuzumab and Hyaluronidase-oysk" @default.
- NCIT_C158060 hasExactSynonym "Trastuzumab and Recombinant Human Hyaluronidase PH20" @default.
- NCIT_C158060 hasExactSynonym "Trastuzumab and rHuPH20" @default.
- NCIT_C158060 hasExactSynonym "Trastuzumab-Hyaluronidase-oysk" @default.
- NCIT_C158060 hasExactSynonym "Trastuzumab/Hyaluronidase-oysk" @default.
- NCIT_C158060 inSubset NCIT_C116977 @default.
- NCIT_C158060 inSubset NCIT_C116978 @default.
- NCIT_C158060 inSubset NCIT_C157711 @default.
- NCIT_C158060 inSubset NCIT_C157712 @default.
- NCIT_C158060 inSubset NCIT_C176424 @default.
- NCIT_C158060 inSubset NCIT_C177537 @default.
- NCIT_C158060 type Class @default.
- NCIT_C158060 isDefinedBy ncit.owl @default.
- NCIT_C158060 label "Trastuzumab/Hyaluronidase-oysk" @default.
- NCIT_C158060 subClassOf NCIT_C129821 @default.
- NCIT_C158060 subClassOf NCIT_C129822 @default.
- NCIT_C158060 subClassOf NCIT_C155711 @default.
- NCIT_C158060 subClassOf NCIT_C158060 @default.
- NCIT_C158060 subClassOf NCIT_C163758 @default.
- NCIT_C158060 subClassOf NCIT_C163760 @default.
- NCIT_C158060 subClassOf NCIT_C1908 @default.
- NCIT_C158060 subClassOf NCIT_C1909 @default.
- NCIT_C158060 subClassOf NCIT_C20401 @default.
- NCIT_C158060 subClassOf NCIT_C274 @default.
- NCIT_C158060 subClassOf NCIT_C307 @default.
- NCIT_C158060 subClassOf NCIT_C308 @default.