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- NCIT_C158067 IAO_0000115 "An antibody drug conjugate (ADC) composed of SP8166 (H01), an anti-folate receptor alpha (FolRa; FOLR1) human immunoglobulin G1 (IgG1) antibody, conjugated to a proprietary cleavable drug linker, SC239, containing a tubulin-targeting 3-aminophenyl hemiasterlin warhead, SC209, with potential antineoplastic activity. Upon intravenous administration, the SP8166 antibody moiety targets and binds to FolRa expressed on certain tumor cells. Upon binding, internalization, and enzymatic cleavage, the cytotoxic SC209 moiety induces tumor cell death in FolRa-expressing cells. FolRa is a glycosylphosphatidylinositol linked cell-surface glycoprotein that is widely expressed in certain cancers including serous and epithelial ovarian cancer, endometrial adenocarcinoma, non-small cell lung cancer and triple negative breast cancer. In contrast, FolRa expression is limited in normal tissues." @default.
- NCIT_C158067 NCIT_A32 NCIT_C1909 @default.
- NCIT_C158067 NCIT_A7 NCIT_C39284 @default.
- NCIT_C158067 NCIT_NHC0 "C158067" @default.
- NCIT_C158067 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C158067 NCIT_P107 "Luveltamab Tazevibulin" @default.
- NCIT_C158067 NCIT_P108 "Luveltamab Tazevibulin" @default.
- NCIT_C158067 NCIT_P208 "CL937710" @default.
- NCIT_C158067 NCIT_P210 "2493327-62-9" @default.
- NCIT_C158067 NCIT_P319 "XDE2GOF1JT" @default.
- NCIT_C158067 NCIT_P322 "CTRP" @default.
- NCIT_C158067 NCIT_P322 "FDA" @default.
- NCIT_C158067 NCIT_P322 "GDC" @default.
- NCIT_C158067 NCIT_P329 "797174" @default.
- NCIT_C158067 NCIT_P330 "797174" @default.
- NCIT_C158067 NCIT_P375 "Anti-Folate Receptor-alpha Antibody Drug Conjugate STRO-002" @default.
- NCIT_C158067 NCIT_P399 "797174" @default.
- NCIT_C158067 normalizedInformationContent "100" @default.
- NCIT_C158067 referenceCount "1" @default.
- NCIT_C158067 hasExactSynonym "Anti-FolRa ADC STRO-002" @default.
- NCIT_C158067 hasExactSynonym "Anti-FolRalpha ADC STRO-002" @default.
- NCIT_C158067 hasExactSynonym "Anti-Folate Receptor-alpha Antibody Drug Conjugate STRO-002" @default.
- NCIT_C158067 hasExactSynonym "LUVELTAMAB TAZEVIBULIN" @default.
- NCIT_C158067 hasExactSynonym "Luveltamab Tazevibulin" @default.
- NCIT_C158067 hasExactSynonym "STRO 002" @default.
- NCIT_C158067 hasExactSynonym "STRO-002" @default.
- NCIT_C158067 hasExactSynonym "STRO002" @default.
- NCIT_C158067 inSubset NCIT_C116977 @default.
- NCIT_C158067 inSubset NCIT_C116978 @default.
- NCIT_C158067 inSubset NCIT_C128784 @default.
- NCIT_C158067 inSubset NCIT_C157711 @default.
- NCIT_C158067 inSubset NCIT_C157712 @default.
- NCIT_C158067 inSubset NCIT_C176424 @default.
- NCIT_C158067 inSubset NCIT_C177537 @default.
- NCIT_C158067 inSubset NCIT_C63923 @default.
- NCIT_C158067 type Class @default.
- NCIT_C158067 isDefinedBy ncit.owl @default.
- NCIT_C158067 label "Luveltamab Tazevibulin" @default.
- NCIT_C158067 subClassOf NCIT_C129821 @default.
- NCIT_C158067 subClassOf NCIT_C129823 @default.
- NCIT_C158067 subClassOf NCIT_C1512 @default.
- NCIT_C158067 subClassOf NCIT_C158067 @default.
- NCIT_C158067 subClassOf NCIT_C163758 @default.
- NCIT_C158067 subClassOf NCIT_C1908 @default.
- NCIT_C158067 subClassOf NCIT_C1909 @default.
- NCIT_C158067 subClassOf NCIT_C200086 @default.
- NCIT_C158067 subClassOf NCIT_C200114 @default.
- NCIT_C158067 subClassOf NCIT_C274 @default.
- NCIT_C158067 subClassOf NCIT_C307 @default.
- NCIT_C158067 subClassOf NCIT_C308 @default.