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- NCIT_C158078 IAO_0000115 "An orally available form of vitamin B3 and precursor of nicotinamide adenine dinucleotide (NAD+) with potential use in the treatment of chemotherapy induced peripheral neuropathy (CIPN). Upon oral administration, nicotinamide riboside (NR) is converted to nicotinamide mononucleotide by the NR kinases, nicotinamide riboside kinase 1 (NRK 1) and nicotinamide riboside kinase 2 (NRK 2), to which a second adenine is transferred by nicotinamide mononucleotide adenylyl transferase to generate NAD+. NAD+, an essential redox coenzyme, may offer protective effects against axonal injury from both mechanical and neurotoxic injury, and maintenance of NAD+ may be protective in mitochondrial disease. NR may help elevate and maintain NAD+ levels, which may ameliorate potential mechanisms implicated in the development of CIPN including mitochondrial dysfunction and peripheral nerve degeneration." @default.
- NCIT_C158078 NCIT_A32 NCIT_C1909 @default.
- NCIT_C158078 NCIT_NHC0 "C158078" @default.
- NCIT_C158078 NCIT_P106 "Organic Chemical" @default.
- NCIT_C158078 NCIT_P106 "Vitamin" @default.
- NCIT_C158078 NCIT_P107 "Nicotinamide Riboside" @default.
- NCIT_C158078 NCIT_P108 "Nicotinamide Riboside" @default.
- NCIT_C158078 NCIT_P208 "CL937699" @default.
- NCIT_C158078 NCIT_P210 "1341-23-7" @default.
- NCIT_C158078 NCIT_P319 "0I8H2M0L7N" @default.
- NCIT_C158078 NCIT_P322 "CTRP" @default.
- NCIT_C158078 NCIT_P322 "FDA" @default.
- NCIT_C158078 NCIT_P322 "GDC" @default.
- NCIT_C158078 NCIT_P329 "797351" @default.
- NCIT_C158078 NCIT_P330 "797351" @default.
- NCIT_C158078 NCIT_P375 "Nicotinamide Riboside" @default.
- NCIT_C158078 NCIT_P399 "797351" @default.
- NCIT_C158078 normalizedInformationContent "100" @default.
- NCIT_C158078 referenceCount "1" @default.
- NCIT_C158078 hasExactSynonym "NICOTINAMIDE RIBOSIDE" @default.
- NCIT_C158078 hasExactSynonym "NR" @default.
- NCIT_C158078 hasExactSynonym "Niagen" @default.
- NCIT_C158078 hasExactSynonym "Nicotinamide Riboside" @default.
- NCIT_C158078 inSubset NCIT_C116977 @default.
- NCIT_C158078 inSubset NCIT_C116978 @default.
- NCIT_C158078 inSubset NCIT_C128784 @default.
- NCIT_C158078 inSubset NCIT_C157711 @default.
- NCIT_C158078 inSubset NCIT_C157712 @default.
- NCIT_C158078 inSubset NCIT_C173381 @default.
- NCIT_C158078 inSubset NCIT_C173383 @default.
- NCIT_C158078 inSubset NCIT_C176424 @default.
- NCIT_C158078 inSubset NCIT_C177537 @default.
- NCIT_C158078 inSubset NCIT_C63923 @default.
- NCIT_C158078 type Class @default.
- NCIT_C158078 isDefinedBy ncit.owl @default.
- NCIT_C158078 label "Nicotinamide Riboside" @default.
- NCIT_C158078 subClassOf NCIT_C1505 @default.
- NCIT_C158078 subClassOf NCIT_C158078 @default.
- NCIT_C158078 subClassOf NCIT_C1908 @default.
- NCIT_C158078 subClassOf NCIT_C1909 @default.
- NCIT_C158078 subClassOf NCIT_C26017 @default.
- NCIT_C158078 subClassOf NCIT_C26170 @default.
- NCIT_C158078 subClassOf NCIT_C275 @default.