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- NCIT_C158082 IAO_0000115 "A synthetic formulation of the Arum palaestinum plant that has been fortified with the already naturally occurring constituents of isovanillin, linolenic acid, and beta-sitosterol, with potential antineoplastic activity. Upon oral administration, GZ17-6.02 may induce apoptosis through caspase-3 activation and poly(ADP-ribose) polymerase (PARP) cleavage, inhibit tumor cell progression by attenuating macrophage infiltration, and inhibit the phosphorylation of several mediators of tumor cell proliferation including Src kinase, extracellular signal-regulated kinases 1 (ERK1) and 2 (ERK2), epidermal growth factor receptor (EGFR), serine/threonine protein kinase AKT (protein kinase B), signal transducer and activator of transcription 2 (STAT-2), and serine/threonine-protein kinase Chk2 (Chk-2). GZ17-6.02 may also inhibit certain super enhancers (SEs) that play an important role in the regulation of the sonic hedgehog (SHH) pathway and cancer stem cell activity. Super enhancers (SEs) are unique areas of the genome that are densely bound by numerous transcription factors and play a pivotal role in the cell, including tissue specification, identity and maintenance. SEs are known to regulate the expression of associated genes and often drive high-level transcription." @default.
- NCIT_C158082 NCIT_A32 NCIT_C1909 @default.
- NCIT_C158082 NCIT_NHC0 "C158082" @default.
- NCIT_C158082 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C158082 NCIT_P108 "Super Enhancer Inhibitor GZ17-6.02" @default.
- NCIT_C158082 NCIT_P208 "CL937695" @default.
- NCIT_C158082 NCIT_P322 "GDC" @default.
- NCIT_C158082 NCIT_P329 "797048" @default.
- NCIT_C158082 NCIT_P330 "797048" @default.
- NCIT_C158082 NCIT_P375 "Super Enhancer Inhibitor GZ17-6.02" @default.
- NCIT_C158082 NCIT_P399 "797048" @default.
- NCIT_C158082 normalizedInformationContent "100" @default.
- NCIT_C158082 referenceCount "1" @default.
- NCIT_C158082 hasExactSynonym "GZ17 6.02" @default.
- NCIT_C158082 hasExactSynonym "GZ17-6.02" @default.
- NCIT_C158082 hasExactSynonym "GZ176.02" @default.
- NCIT_C158082 hasExactSynonym "Super Enhancer Inhibitor GZ17-6.02" @default.
- NCIT_C158082 hasExactSynonym "Synthetic Arum palaestinum derivative GZ17-6.02" @default.
- NCIT_C158082 inSubset NCIT_C128784 @default.
- NCIT_C158082 inSubset NCIT_C157711 @default.
- NCIT_C158082 inSubset NCIT_C157712 @default.
- NCIT_C158082 inSubset NCIT_C176424 @default.
- NCIT_C158082 inSubset NCIT_C177537 @default.
- NCIT_C158082 type Class @default.
- NCIT_C158082 isDefinedBy ncit.owl @default.
- NCIT_C158082 label "Super Enhancer Inhibitor GZ17-6.02" @default.
- NCIT_C158082 subClassOf NCIT_C129839 @default.
- NCIT_C158082 subClassOf NCIT_C158082 @default.
- NCIT_C158082 subClassOf NCIT_C1908 @default.
- NCIT_C158082 subClassOf NCIT_C1909 @default.
- NCIT_C158082 subClassOf NCIT_C274 @default.