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- NCIT_C158086 IAO_0000115 "An orally bioavailable non-nucleoside inhibitor of the polymerase basic protein 2 (PB2) subunit of the influenza A virus polymerase complex with potential antiviral activity. Upon administration, pimodivir occupies the 7-methyl GTP (m7GTP) binding site of PB2, thereby blocking the cap-snatching activity of the influenza polymerase complex and inhibiting the synthesis of viral mRNA. PB2 is one of three subunits that make up the influenza A viral polymerase complex, which is responsible for replication and transcription of the viral RNA (vRNA) genome in the nuclei of infected cells." @default.
- NCIT_C158086 NCIT_NHC0 "C158086" @default.
- NCIT_C158086 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C158086 NCIT_P108 "Pimodivir" @default.
- NCIT_C158086 NCIT_P208 "CL937691" @default.
- NCIT_C158086 NCIT_P210 "1629869-44-8" @default.
- NCIT_C158086 NCIT_P319 "DFC121MXC3" @default.
- NCIT_C158086 NCIT_P322 "FDA" @default.
- NCIT_C158086 NCIT_P329 "797081" @default.
- NCIT_C158086 NCIT_P330 "797081" @default.
- NCIT_C158086 NCIT_P399 "797081" @default.
- NCIT_C158086 normalizedInformationContent "100" @default.
- NCIT_C158086 referenceCount "1" @default.
- NCIT_C158086 hasExactSynonym "JNJ 63623872" @default.
- NCIT_C158086 hasExactSynonym "JNJ-63623872" @default.
- NCIT_C158086 hasExactSynonym "JNJ63623872" @default.
- NCIT_C158086 hasExactSynonym "PIMODIVIR" @default.
- NCIT_C158086 hasExactSynonym "Pimodivir" @default.
- NCIT_C158086 hasExactSynonym "VX 787" @default.
- NCIT_C158086 hasExactSynonym "VX-787" @default.
- NCIT_C158086 hasExactSynonym "VX787" @default.
- NCIT_C158086 inSubset NCIT_C176424 @default.
- NCIT_C158086 inSubset NCIT_C63923 @default.
- NCIT_C158086 type Class @default.
- NCIT_C158086 isDefinedBy ncit.owl @default.
- NCIT_C158086 label "Pimodivir" @default.
- NCIT_C158086 subClassOf NCIT_C158086 @default.
- NCIT_C158086 subClassOf NCIT_C1908 @default.
- NCIT_C158086 subClassOf NCIT_C1909 @default.
- NCIT_C158086 subClassOf NCIT_C254 @default.
- NCIT_C158086 subClassOf NCIT_C281 @default.