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- NCIT_C158087 IAO_0000115 "A preparation of T-lymphocytes that have been genetically modified to express a dual-targeted chimeric antigen receptor (CAR) recognizing the tumor-associated antigens (TAAs), cluster of differentiation 38 (CD38) and B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17), with potential immunostimulating and antineoplastic activities. Upon intravenous administration, the anti-CD38/BCMA CAR T-cells are directed to and induce selective toxicity in both CD38- and BCMA-expressing cells. CD38, a type II transmembrane glycoprotein, is present on various immune cells and hematologic malignancies, and its expression has been correlated with poor prognosis. BCMA is found on the surfaces of plasma cells and is and overexpressed on malignant plasma cells." @default.
- NCIT_C158087 NCIT_NHC0 "C158087" @default.
- NCIT_C158087 NCIT_P106 "Cell" @default.
- NCIT_C158087 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C158087 NCIT_P108 "Anti-CD38/BCMA CAR T-lymphocytes" @default.
- NCIT_C158087 NCIT_P208 "CL937692" @default.
- NCIT_C158087 NCIT_P329 "797082" @default.
- NCIT_C158087 NCIT_P330 "797082" @default.
- NCIT_C158087 NCIT_P399 "797082" @default.
- NCIT_C158087 normalizedInformationContent "100" @default.
- NCIT_C158087 referenceCount "1" @default.
- NCIT_C158087 hasExactSynonym "Anti-CD38/Anti-BCMA CAR T-cells" @default.
- NCIT_C158087 hasExactSynonym "Anti-CD38/Anti-BCMA CAR T-lymphocytes" @default.
- NCIT_C158087 hasExactSynonym "Anti-CD38/BCMA CAR T-cells" @default.
- NCIT_C158087 hasExactSynonym "Anti-CD38/BCMA CAR T-lymphocytes" @default.
- NCIT_C158087 inSubset NCIT_C128784 @default.
- NCIT_C158087 inSubset NCIT_C176424 @default.
- NCIT_C158087 type Class @default.
- NCIT_C158087 isDefinedBy ncit.owl @default.
- NCIT_C158087 label "Anti-CD38/BCMA CAR T-lymphocytes" @default.
- NCIT_C158087 subClassOf NCIT_C129820 @default.
- NCIT_C158087 subClassOf NCIT_C129821 @default.
- NCIT_C158087 subClassOf NCIT_C129826 @default.
- NCIT_C158087 subClassOf NCIT_C137999 @default.
- NCIT_C158087 subClassOf NCIT_C142078 @default.
- NCIT_C158087 subClassOf NCIT_C154231 @default.
- NCIT_C158087 subClassOf NCIT_C158087 @default.
- NCIT_C158087 subClassOf NCIT_C176023 @default.
- NCIT_C158087 subClassOf NCIT_C1908 @default.
- NCIT_C158087 subClassOf NCIT_C1909 @default.
- NCIT_C158087 subClassOf NCIT_C1962 @default.
- NCIT_C158087 subClassOf NCIT_C201510 @default.
- NCIT_C158087 subClassOf NCIT_C274 @default.
- NCIT_C158087 subClassOf NCIT_C307 @default.
- NCIT_C158087 subClassOf NCIT_C308 @default.