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- NCIT_C158103 IAO_0000115 "An orally available inhibitor of dihydroorotate dehydrogenase (DHODH), with potential antineoplastic activity. Upon administration, AG-636 specifically targets, binds to and prevents the activation of DHODH, thereby preventing the fourth enzymatic step in de novo pyrimidine synthesis. This prevents uridine monophosphate (UMP) formation, DNA synthesis, cell division and cellular proliferation, causes reactive oxygen species (ROS) formation, enables differentiation and induces apoptosis in susceptible tumor cells. DHODH, a mitochondrial enzyme, catalyzes the conversion of dihydroorotate (DHO) to orotate in the endogenous synthesis of UMP." @default.
- NCIT_C158103 NCIT_A32 NCIT_C1909 @default.
- NCIT_C158103 NCIT_A7 NCIT_C17289 @default.
- NCIT_C158103 NCIT_NHC0 "C158103" @default.
- NCIT_C158103 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C158103 NCIT_P107 "Dihydroorotate Dehydrogenase Inhibitor AG-636" @default.
- NCIT_C158103 NCIT_P108 "Dihydroorotate Dehydrogenase Inhibitor AG-636" @default.
- NCIT_C158103 NCIT_P208 "CL937737" @default.
- NCIT_C158103 NCIT_P322 "CTRP" @default.
- NCIT_C158103 NCIT_P322 "GDC" @default.
- NCIT_C158103 NCIT_P329 "797356" @default.
- NCIT_C158103 NCIT_P330 "797356" @default.
- NCIT_C158103 NCIT_P375 "Dihydroorotate Dehydrogenase Inhibitor AG-636" @default.
- NCIT_C158103 NCIT_P399 "797356" @default.
- NCIT_C158103 normalizedInformationContent "100" @default.
- NCIT_C158103 referenceCount "1" @default.
- NCIT_C158103 hasExactSynonym "AG 636" @default.
- NCIT_C158103 hasExactSynonym "AG-636" @default.
- NCIT_C158103 hasExactSynonym "AG636" @default.
- NCIT_C158103 hasExactSynonym "DHODH Inhibitor AG-636" @default.
- NCIT_C158103 hasExactSynonym "Dihydroorotate Dehydrogenase Inhibitor AG-636" @default.
- NCIT_C158103 inSubset NCIT_C116977 @default.
- NCIT_C158103 inSubset NCIT_C116978 @default.
- NCIT_C158103 inSubset NCIT_C157711 @default.
- NCIT_C158103 inSubset NCIT_C157712 @default.
- NCIT_C158103 inSubset NCIT_C176424 @default.
- NCIT_C158103 inSubset NCIT_C177537 @default.
- NCIT_C158103 type Class @default.
- NCIT_C158103 isDefinedBy ncit.owl @default.
- NCIT_C158103 label "Dihydroorotate Dehydrogenase Inhibitor AG-636" @default.
- NCIT_C158103 subClassOf NCIT_C158103 @default.
- NCIT_C158103 subClassOf NCIT_C1908 @default.
- NCIT_C158103 subClassOf NCIT_C1909 @default.
- NCIT_C158103 subClassOf NCIT_C2169 @default.
- NCIT_C158103 subClassOf NCIT_C308 @default.
- NCIT_C158103 subClassOf NCIT_C471 @default.
- NCIT_C158103 subClassOf NCIT_C574 @default.