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- NCIT_C1584 IAO_0000115 "The hydrochloride salt form of loperamide, a synthetic, piperidine derivative and opioid agonist with antidiarrheal activity. Loperamide acts on the mu-receptors in the intestinal mucosa. This leads to a decrease in gastrointestinal motility by decreasing the circular and longitudinal smooth muscle activity of the intestinal wall. This slows intestinal transit and allows for more water and electrolyte absorption from the intestines. Loperamide is not significantly absorbed from the gut and does not cross the blood-brain barrier. Therefore it has no central nervous system effects." @default.
- NCIT_C1584 NCIT_A6 NCIT_C618 @default.
- NCIT_C1584 NCIT_NHC0 "C1584" @default.
- NCIT_C1584 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1584 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1584 NCIT_P108 "Loperamide Hydrochloride" @default.
- NCIT_C1584 NCIT_P207 "C0282221" @default.
- NCIT_C1584 NCIT_P210 "34552-83-5" @default.
- NCIT_C1584 NCIT_P319 "77TI35393C" @default.
- NCIT_C1584 NCIT_P322 "FDA" @default.
- NCIT_C1584 NCIT_P325 "A drug used to treat diarrhea. Imodium slows the movement of the muscles in the small intestine to allow more water to be taken out of the feces (waste matter) and more nutrients to be absorbed." @default.
- NCIT_C1584 NCIT_P329 "41911" @default.
- NCIT_C1584 NCIT_P330 "41911" @default.
- NCIT_C1584 NCIT_P350 "C29H33ClN2O2.HCl" @default.
- NCIT_C1584 NCIT_P366 "Loperamide_Hydrochloride" @default.
- NCIT_C1584 NCIT_P399 "41911" @default.
- NCIT_C1584 normalizedInformationContent "100" @default.
- NCIT_C1584 referenceCount "1" @default.
- NCIT_C1584 hasExactSynonym "Imodium A-D" @default.
- NCIT_C1584 hasExactSynonym "Imodium" @default.
- NCIT_C1584 hasExactSynonym "LOPERAMIDE HYDROCHLORIDE" @default.
- NCIT_C1584 hasExactSynonym "Loperamide Hydrochloride" @default.
- NCIT_C1584 hasExactSynonym "loperamide hydrochloride" @default.
- NCIT_C1584 inSubset NCIT_C176424 @default.
- NCIT_C1584 inSubset NCIT_C63923 @default.
- NCIT_C1584 type Class @default.
- NCIT_C1584 isDefinedBy ncit.owl @default.
- NCIT_C1584 label "Loperamide Hydrochloride" @default.
- NCIT_C1584 subClassOf NCIT_C1584 @default.
- NCIT_C1584 subClassOf NCIT_C1908 @default.
- NCIT_C1584 subClassOf NCIT_C1909 @default.
- NCIT_C1584 subClassOf NCIT_C266 @default.
- NCIT_C1584 subClassOf NCIT_C78276 @default.