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- NCIT_C158504 IAO_0000115 "A human bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFvs): one directed again the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; tumor necrosis factor receptor superfamily member 17; TNFRSF17) and another directed against the CD3 antigen expressed on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration, linvoseltamab binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and BCMA on BCMA-expressing tumor cells. This activates and redirects CTLs to BCMA-expressing tumor cells, leading to CTL-mediated killing of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival." @default.
- NCIT_C158504 NCIT_A32 NCIT_C1909 @default.
- NCIT_C158504 NCIT_A7 NCIT_C97848 @default.
- NCIT_C158504 NCIT_NHC0 "C158504" @default.
- NCIT_C158504 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C158504 NCIT_P107 "Linvoseltamab" @default.
- NCIT_C158504 NCIT_P108 "Linvoseltamab" @default.
- NCIT_C158504 NCIT_P208 "CL938057" @default.
- NCIT_C158504 NCIT_P210 "2408319-25-3" @default.
- NCIT_C158504 NCIT_P319 "M3CPC50MZS" @default.
- NCIT_C158504 NCIT_P322 "CTRP" @default.
- NCIT_C158504 NCIT_P322 "FDA" @default.
- NCIT_C158504 NCIT_P322 "GDC" @default.
- NCIT_C158504 NCIT_P329 "797141" @default.
- NCIT_C158504 NCIT_P330 "797141" @default.
- NCIT_C158504 NCIT_P375 "Anti-BCMA/CD3 BiTE Antibody REGN5458" @default.
- NCIT_C158504 NCIT_P399 "797141" @default.
- NCIT_C158504 NCIT_R124 NCIT_C17710 @default.
- NCIT_C158504 NCIT_R124 NCIT_C17828 @default.
- NCIT_C158504 NCIT_R124 NCIT_C18219 @default.
- NCIT_C158504 NCIT_R124 NCIT_C19986 @default.
- NCIT_C158504 NCIT_R124 NCIT_C40474 @default.
- NCIT_C158504 normalizedInformationContent "100" @default.
- NCIT_C158504 referenceCount "1" @default.
- NCIT_C158504 hasExactSynonym "Anti-BCMA x Anti-CD3 BiTE REGN5458" @default.
- NCIT_C158504 hasExactSynonym "Anti-BCMA/CD3 BiTE Antibody REGN5458" @default.
- NCIT_C158504 hasExactSynonym "BiTE Antibody REGN5458" @default.
- NCIT_C158504 hasExactSynonym "Bispecific BCMA x CD3 T-cell Engaging Antibody REGN5458" @default.
- NCIT_C158504 hasExactSynonym "LINVOSELTAMAB" @default.
- NCIT_C158504 hasExactSynonym "Linvoseltamab" @default.
- NCIT_C158504 hasExactSynonym "REGN 5458" @default.
- NCIT_C158504 hasExactSynonym "REGN-5458" @default.
- NCIT_C158504 hasExactSynonym "REGN5458" @default.
- NCIT_C158504 inSubset NCIT_C116977 @default.
- NCIT_C158504 inSubset NCIT_C116978 @default.
- NCIT_C158504 inSubset NCIT_C128784 @default.
- NCIT_C158504 inSubset NCIT_C157711 @default.
- NCIT_C158504 inSubset NCIT_C157712 @default.
- NCIT_C158504 inSubset NCIT_C176424 @default.
- NCIT_C158504 inSubset NCIT_C177537 @default.
- NCIT_C158504 inSubset NCIT_C63923 @default.
- NCIT_C158504 type Class @default.
- NCIT_C158504 isDefinedBy ncit.owl @default.
- NCIT_C158504 label "Linvoseltamab" @default.
- NCIT_C158504 subClassOf NCIT_C112883 @default.
- NCIT_C158504 subClassOf NCIT_C129821 @default.
- NCIT_C158504 subClassOf NCIT_C129822 @default.
- NCIT_C158504 subClassOf NCIT_C1454 @default.
- NCIT_C158504 subClassOf NCIT_C158504 @default.
- NCIT_C158504 subClassOf NCIT_C163758 @default.
- NCIT_C158504 subClassOf NCIT_C181111 @default.
- NCIT_C158504 subClassOf NCIT_C181113 @default.
- NCIT_C158504 subClassOf NCIT_C181114 @default.
- NCIT_C158504 subClassOf NCIT_C1908 @default.
- NCIT_C158504 subClassOf NCIT_C1909 @default.
- NCIT_C158504 subClassOf NCIT_C201282 @default.
- NCIT_C158504 subClassOf NCIT_C20401 @default.
- NCIT_C158504 subClassOf NCIT_C274 @default.
- NCIT_C158504 subClassOf NCIT_C28227 @default.
- NCIT_C158504 subClassOf NCIT_C307 @default.
- NCIT_C158504 subClassOf NCIT_C308 @default.