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- NCIT_C158507 IAO_0000115 "An agonistic fully human anti-OX40 (tumor necrosis factor receptor superfamily member 4; TNFRSF4; CD134; OX40L receptor) with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, cudarolimab selectively binds to and activates OX40. Receptor activation induces proliferation of memory and effector T-lymphocytes and results in a T-cell-mediated immune response against tumor cells, which leads to tumor cell lysis. OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes and provides a co-stimulatory signal that promotes both the proliferation and survival of activated T-cells." @default.
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- NCIT_C158507 NCIT_NHC0 "C158507" @default.
- NCIT_C158507 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C158507 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C158507 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C158507 NCIT_P107 "Cudarolimab" @default.
- NCIT_C158507 NCIT_P108 "Cudarolimab" @default.
- NCIT_C158507 NCIT_P208 "CL938052" @default.
- NCIT_C158507 NCIT_P210 "2244739-29-3" @default.
- NCIT_C158507 NCIT_P319 "DT958C4NWR" @default.
- NCIT_C158507 NCIT_P322 "CTRP" @default.
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- NCIT_C158507 NCIT_P329 "797150" @default.
- NCIT_C158507 NCIT_P330 "797150" @default.
- NCIT_C158507 NCIT_P375 "Anti-OX40 Monoclonal Antibody IBI101" @default.
- NCIT_C158507 NCIT_P399 "797150" @default.
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- NCIT_C158507 normalizedInformationContent "100" @default.
- NCIT_C158507 referenceCount "1" @default.
- NCIT_C158507 hasExactSynonym "Anti-OX40 Monoclonal Antibody IBI101" @default.
- NCIT_C158507 hasExactSynonym "CUDAROLIMAB" @default.
- NCIT_C158507 hasExactSynonym "Cudarolimab" @default.
- NCIT_C158507 hasExactSynonym "IBI 101" @default.
- NCIT_C158507 hasExactSynonym "IBI-101" @default.
- NCIT_C158507 hasExactSynonym "IBI101" @default.
- NCIT_C158507 inSubset NCIT_C116977 @default.
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- NCIT_C158507 type Class @default.
- NCIT_C158507 isDefinedBy ncit.owl @default.
- NCIT_C158507 label "Cudarolimab" @default.
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- NCIT_C158507 subClassOf NCIT_C307 @default.
- NCIT_C158507 subClassOf NCIT_C308 @default.
- NCIT_C158507 subClassOf NCIT_C96040 @default.