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- NCIT_C158515 IAO_0000115 "An eicosapentaenoic acid derivative with potential antineoplastic activities. Upon oral administration, eicosapentaenoic acid monoacylglyceride (MAG-EPA) may inhibit epidermal growth factor receptor (EGFR), vascular endothelial growth factor receptor (VEGFR) and serine/threonine protein kinase AKT (protein kinase B)-mediated signaling pathways and reduce vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1-alpha (HIF1-alpha) expression levels in tumor cells. This may promote apoptosis and inhibit tumor cell growth in cells expressing EGFR, AKT, and VEGFR. MAG-EPA may also inhibit androgen-stimulated tumor cell growth and repress androgenic induction of prostate-specific antigen (PSA) expression. PSA, a tumor associated antigen (TAA), is expressed by prostate epithelial cells and is overexpressed in prostate cancer. The AKT signaling pathway is often dysregulated in cancer and is associated with tumor cell proliferation, survival and migration. EGFR and VGFR are receptor tyrosine kinases that are mutated or upregulated in many tumor cell types and play a key role in tumor cell proliferation and tumor vascularization." @default.
- NCIT_C158515 NCIT_NHC0 "C158515" @default.
- NCIT_C158515 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C158515 NCIT_P108 "Eicosapentaenoic Acid Monoacylglyceride" @default.
- NCIT_C158515 NCIT_P208 "CL938045" @default.
- NCIT_C158515 NCIT_P329 "797223" @default.
- NCIT_C158515 NCIT_P330 "797223" @default.
- NCIT_C158515 NCIT_P399 "797223" @default.
- NCIT_C158515 normalizedInformationContent "100" @default.
- NCIT_C158515 referenceCount "1" @default.
- NCIT_C158515 hasExactSynonym "Eicosapentaenoic Acid Monoacylglyceride" @default.
- NCIT_C158515 hasExactSynonym "MAG-EPA" @default.
- NCIT_C158515 hasExactSynonym "Monoglyceride Eicosapentaenoic Acid" @default.
- NCIT_C158515 inSubset NCIT_C128784 @default.
- NCIT_C158515 inSubset NCIT_C176424 @default.
- NCIT_C158515 type Class @default.
- NCIT_C158515 isDefinedBy ncit.owl @default.
- NCIT_C158515 label "Eicosapentaenoic Acid Monoacylglyceride" @default.
- NCIT_C158515 subClassOf NCIT_C1505 @default.
- NCIT_C158515 subClassOf NCIT_C158515 @default.
- NCIT_C158515 subClassOf NCIT_C1908 @default.