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- NCIT_C158517 IAO_0000115 "An orally bioavailable, small molecule tubulin inhibitor, with potential antineoplastic, antiviral and anti-inflammatory activities. Upon oral administration, sabizabulin binds to the colchicine-binding site of alpha- and beta-tubulin subunits of microtubules and crosslinks the microtubules, thereby inhibiting microtubule polymerization in tumor blood vessel endothelial cells and tumor cells. This blocks the formation of the mitotic spindle and leads to cell cycle arrest at the G2/M phase. As a result, this agent disrupts the tumor vasculature, tumor blood flow, deprives tumor cells of nutrients, and induces apoptosis. In addition, as microtubules plays an important role in intracellular transport, the inhibition of its polymerization may disrupt the transport of the androgen receptor (AR) into the cell nucleus, as well as virus trafficking around the cell. This may decrease viral replication and assembly. Inhibition of tubulin polymerization may also inhibit the release of pro-inflammatory cytokines and disrupt inflammatory cell activities. Sabizabulin is not a substrate of P-glycoprotein (Pgp), an efflux pump that when overexpressed, may confer resistance to taxane agents." @default.
- NCIT_C158517 NCIT_A32 NCIT_C1909 @default.
- NCIT_C158517 NCIT_A7 NCIT_C129386 @default.
- NCIT_C158517 NCIT_A7 NCIT_C129655 @default.
- NCIT_C158517 NCIT_NHC0 "C158517" @default.
- NCIT_C158517 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C158517 NCIT_P107 "Sabizabulin" @default.
- NCIT_C158517 NCIT_P108 "Sabizabulin" @default.
- NCIT_C158517 NCIT_P208 "CL1659534" @default.
- NCIT_C158517 NCIT_P210 "1332881-26-1" @default.
- NCIT_C158517 NCIT_P319 "37L1JX37J5" @default.
- NCIT_C158517 NCIT_P322 "CTRP" @default.
- NCIT_C158517 NCIT_P322 "FDA" @default.
- NCIT_C158517 NCIT_P322 "GDC" @default.
- NCIT_C158517 NCIT_P329 "797224" @default.
- NCIT_C158517 NCIT_P330 "797224" @default.
- NCIT_C158517 NCIT_P375 "Tubulin Polymerization Inhibitor VERU-111" @default.
- NCIT_C158517 NCIT_P399 "797224" @default.
- NCIT_C158517 NCIT_R124 NCIT_C17828 @default.
- NCIT_C158517 NCIT_R124 NCIT_C20480 @default.
- NCIT_C158517 NCIT_R124 NCIT_C40795 @default.
- NCIT_C158517 NCIT_R124 NCIT_C40798 @default.
- NCIT_C158517 normalizedInformationContent "100" @default.
- NCIT_C158517 referenceCount "1" @default.
- NCIT_C158517 hasExactSynonym "SABIZABULIN" @default.
- NCIT_C158517 hasExactSynonym "Sabizabulin" @default.
- NCIT_C158517 hasExactSynonym "VERU 111" @default.
- NCIT_C158517 hasExactSynonym "VERU-111" @default.
- NCIT_C158517 hasExactSynonym "VERU111" @default.
- NCIT_C158517 inSubset NCIT_C116977 @default.
- NCIT_C158517 inSubset NCIT_C116978 @default.
- NCIT_C158517 inSubset NCIT_C128784 @default.
- NCIT_C158517 inSubset NCIT_C157711 @default.
- NCIT_C158517 inSubset NCIT_C157712 @default.
- NCIT_C158517 inSubset NCIT_C173381 @default.
- NCIT_C158517 inSubset NCIT_C173383 @default.
- NCIT_C158517 inSubset NCIT_C176424 @default.
- NCIT_C158517 inSubset NCIT_C177537 @default.
- NCIT_C158517 inSubset NCIT_C63923 @default.
- NCIT_C158517 type Class @default.
- NCIT_C158517 isDefinedBy ncit.owl @default.
- NCIT_C158517 label "Sabizabulin" @default.
- NCIT_C158517 subClassOf NCIT_C158517 @default.
- NCIT_C158517 subClassOf NCIT_C186664 @default.
- NCIT_C158517 subClassOf NCIT_C1908 @default.
- NCIT_C158517 subClassOf NCIT_C1909 @default.
- NCIT_C158517 subClassOf NCIT_C25974 @default.
- NCIT_C158517 subClassOf NCIT_C273 @default.
- NCIT_C158517 subClassOf NCIT_C274 @default.