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- NCIT_C158522 IAO_0000115 "A cancer cell vaccine consisting of autologous dendritic cells pulsed with mRNA encoding the human cytomegalovirus (CMV) matrix protein pp65 (65 kDa lower matrix phosphoprotein; UL83) as a fusion construct with a short peptide chimeric antigen from lysosome-associated membrane protein 1 (shLAMP-1), with potential antineoplastic and immunostimulatory activities. Upon vaccination, the autologous CMV-pp65-shLAMP-1 vaccine exposes the immune system to the CMV pp65 peptide, which may elicit a cytotoxic T-lymphocyte (CTL) response against CMV pp65-expressing tumor cells. The incorporation of shLAMP-1 may route CMV pp-65 antigens into the lysosomal compartment, resulting in enhanced MHC class II antigen presentation, thereby promoting CD4-positive T-cell responses. The CMV pp65 protein is the primary component of the enveloped sub-viral particle of CMV and is expressed in certain tumor types." @default.
- NCIT_C158522 NCIT_A7 NCIT_C141213 @default.
- NCIT_C158522 NCIT_NHC0 "C158522" @default.
- NCIT_C158522 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C158522 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C158522 NCIT_P107 "Autologous CMV-pp65-shLAMP-1 mRNA Loaded Dendritic Cell Vaccine" @default.
- NCIT_C158522 NCIT_P108 "Autologous CMV-pp65-shLAMP-1 mRNA Loaded Dendritic Cell Vaccine" @default.
- NCIT_C158522 NCIT_P208 "CL937978" @default.
- NCIT_C158522 NCIT_P322 "CTRP" @default.
- NCIT_C158522 NCIT_P329 "797472" @default.
- NCIT_C158522 NCIT_P330 "797472" @default.
- NCIT_C158522 NCIT_P399 "797472" @default.
- NCIT_C158522 normalizedInformationContent "100" @default.
- NCIT_C158522 referenceCount "1" @default.
- NCIT_C158522 hasExactSynonym "Autologous CMV-pp65-shLAMP-1 mRNA Loaded Dendritic Cell Vaccine" @default.
- NCIT_C158522 hasExactSynonym "Autologous pp65-shLAMP-1 DC Vaccine" @default.
- NCIT_C158522 hasExactSynonym "Autologous shLAMP-1-pp65 mRNA-pulsed DC Vaccine" @default.
- NCIT_C158522 hasExactSynonym "Autologous shLAMP-1-pp65-DC Vaccine" @default.
- NCIT_C158522 hasExactSynonym "Autologous shLAMP-1-pp65-DCs" @default.
- NCIT_C158522 hasExactSynonym "pp65-shLAMP-1 mRNA DCs" @default.
- NCIT_C158522 inSubset NCIT_C116977 @default.
- NCIT_C158522 inSubset NCIT_C116978 @default.
- NCIT_C158522 inSubset NCIT_C128784 @default.
- NCIT_C158522 inSubset NCIT_C176424 @default.
- NCIT_C158522 type Class @default.
- NCIT_C158522 isDefinedBy ncit.owl @default.
- NCIT_C158522 label "Autologous CMV-pp65-shLAMP-1 mRNA Loaded Dendritic Cell Vaccine" @default.
- NCIT_C158522 subClassOf NCIT_C129820 @default.
- NCIT_C158522 subClassOf NCIT_C158522 @default.
- NCIT_C158522 subClassOf NCIT_C1663 @default.
- NCIT_C158522 subClassOf NCIT_C172787 @default.
- NCIT_C158522 subClassOf NCIT_C181141 @default.
- NCIT_C158522 subClassOf NCIT_C1908 @default.
- NCIT_C158522 subClassOf NCIT_C1909 @default.
- NCIT_C158522 subClassOf NCIT_C274 @default.
- NCIT_C158522 subClassOf NCIT_C28308 @default.
- NCIT_C158522 subClassOf NCIT_C28310 @default.
- NCIT_C158522 subClassOf NCIT_C307 @default.
- NCIT_C158522 subClassOf NCIT_C308 @default.
- NCIT_C158522 subClassOf NCIT_C923 @default.