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- NCIT_C158599 IAO_0000115 "A preparation of autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) specific for the tumor-associated antigen (TAA) cluster of differentiation 19 (CD19), carrying cytoplasmic activated programmed cell death 1 (PD1; PDCD1; CD279; programmed death-1), with potential antineoplastic activity. Upon intravenous administration, autologous cytoplasmic activated PD-1 CAR T-cells target, bind to, and induce selective toxicity in CD19-expressing tumor cells. The cytoplasmic activated PD1, a negative immunoregulatory human cell surface receptor, normally binds to programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274) on tumor cells, causing T-cell inactivation. By preventing PD1/PD-L1 signaling, T-cell exhaustion is abrogated, and T-cell activation is enhanced leading to an increased cytotoxic T-lymphocyte (CTL)-mediated anti-tumor immune response against PD-L1-expressing tumor cells. CD19 is a B-cell-specific cell surface antigen overexpressed in B-cell lineage tumors." @default.
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- NCIT_C158599 NCIT_P108 "Autologous Cytoplasmic Activated PD-1 CAR T-cells" @default.
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- NCIT_C158599 hasExactSynonym "Autologous CAR19 T-cells Carrying Cytoplasmic Activated PD-1" @default.
- NCIT_C158599 hasExactSynonym "Autologous Cytoplasmic Activated PD-1 CAR T-cells" @default.
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- NCIT_C158599 label "Autologous Cytoplasmic Activated PD-1 CAR T-cells" @default.
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