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- NCIT_C158602 IAO_0000115 "A preparation of human T-lymphocytes transduced with a retroviral vector encoding an anti-epidermal growth factor receptor (EGFR) chimeric antigen receptor (CAR) gene coupled to the signaling domains from CD28, 4-1BB (CD137) and CD3 zeta, and modified to express the cytokine interleukin-12 (IL-12), with potential immunostimulatory and antineoplastic activities. Upon administration, the anti-EGFR CAR-transduced IL-12-expressing T-lymphocytes target and bind to the EGFR antigen on tumor cell surfaces; subsequently, EGFR-expressing tumor cells may be lysed. IL-12 expression activates the immune system by promoting the secretion of interferon-gamma (IFNg), activating natural killer cells (NKs), and inducing cytotoxic T-cell responses, which may result in both decreased cell proliferation and increased cell death for the EGFR-overexpressing tumor cells. EGFR, overexpressed by a variety of cancer cell types, plays a key role in tumor cell proliferation, tumor angiogenesis and radio- and chemoresistance." @default.
- NCIT_C158602 NCIT_NHC0 "C158602" @default.
- NCIT_C158602 NCIT_P106 "Cell" @default.
- NCIT_C158602 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C158602 NCIT_P108 "Anti-EGFR CAR-transduced IL-12-expressing T-lymphocytes" @default.
- NCIT_C158602 NCIT_P208 "CL938079" @default.
- NCIT_C158602 NCIT_P329 "797091" @default.
- NCIT_C158602 NCIT_P330 "797091" @default.
- NCIT_C158602 NCIT_P399 "797091" @default.
- NCIT_C158602 normalizedInformationContent "100" @default.
- NCIT_C158602 referenceCount "1" @default.
- NCIT_C158602 hasExactSynonym "Anti-EGFR CAR-transduced IL-12-expressing T-lymphocytes" @default.
- NCIT_C158602 hasExactSynonym "EGFR-IL12-CAR T-cells" @default.
- NCIT_C158602 inSubset NCIT_C128784 @default.
- NCIT_C158602 inSubset NCIT_C176424 @default.
- NCIT_C158602 type Class @default.
- NCIT_C158602 isDefinedBy ncit.owl @default.
- NCIT_C158602 label "Anti-EGFR CAR-transduced IL-12-expressing T-lymphocytes" @default.
- NCIT_C158602 subClassOf NCIT_C129820 @default.
- NCIT_C158602 subClassOf NCIT_C129821 @default.
- NCIT_C158602 subClassOf NCIT_C129826 @default.
- NCIT_C158602 subClassOf NCIT_C137999 @default.
- NCIT_C158602 subClassOf NCIT_C142078 @default.
- NCIT_C158602 subClassOf NCIT_C154231 @default.
- NCIT_C158602 subClassOf NCIT_C158602 @default.
- NCIT_C158602 subClassOf NCIT_C1908 @default.
- NCIT_C158602 subClassOf NCIT_C1909 @default.
- NCIT_C158602 subClassOf NCIT_C1962 @default.
- NCIT_C158602 subClassOf NCIT_C201175 @default.
- NCIT_C158602 subClassOf NCIT_C274 @default.
- NCIT_C158602 subClassOf NCIT_C307 @default.
- NCIT_C158602 subClassOf NCIT_C308 @default.