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- NCIT_C158603 IAO_0000115 "An orally bioavailable inhibitor of the class I phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K) catalytic subunit alpha (PIK3CA), with potential antineoplastic activity. Upon administration, izorlisib selectively binds to and inhibits PIK3CA and its mutated forms in the PI3K/Akt (protein kinase B)/mammalian target of rapamycin (mTOR) pathway. This results in both apoptosis and growth inhibition in PIK3CA-expressing tumor cells. By specifically targeting PIK3CA, izorlisib may be more efficacious and less toxic than pan-PI3K inhibitors. In addition, izorlisib also targets mutated forms of PI3K gamma (PI3Kg). It may also stimulate the immune system to restore CD8+ T-cell activation and cytotoxicity. Dysregulation of the PI3K/Akt/mTOR pathway is often found in solid tumors and results in the promotion of tumor cell growth, survival, and resistance to chemo- and radio-therapy. PIK3CA, one of the most frequently mutated oncogenes, encodes the p110-alpha catalytic subunit of the class I PI3K. In most solid tumors, the activation of the PI3K pathway is induced by mutations of PIK3CA." @default.
- NCIT_C158603 NCIT_A32 NCIT_C1909 @default.
- NCIT_C158603 NCIT_A7 NCIT_C30168 @default.
- NCIT_C158603 NCIT_NHC0 "C158603" @default.
- NCIT_C158603 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C158603 NCIT_P107 "Izorlisib" @default.
- NCIT_C158603 NCIT_P108 "Izorlisib" @default.
- NCIT_C158603 NCIT_P208 "CL938076" @default.
- NCIT_C158603 NCIT_P210 "1007207-67-1" @default.
- NCIT_C158603 NCIT_P319 "JCL936W835" @default.
- NCIT_C158603 NCIT_P322 "CTRP" @default.
- NCIT_C158603 NCIT_P322 "FDA" @default.
- NCIT_C158603 NCIT_P322 "GDC" @default.
- NCIT_C158603 NCIT_P329 "797093" @default.
- NCIT_C158603 NCIT_P330 "797093" @default.
- NCIT_C158603 NCIT_P375 "PI3K-alpha Inhibitor MEN1611" @default.
- NCIT_C158603 NCIT_P399 "797093" @default.
- NCIT_C158603 normalizedInformationContent "100" @default.
- NCIT_C158603 referenceCount "1" @default.
- NCIT_C158603 hasExactSynonym "5-(7-Methylsulfonyl-2-morpholin-4-yl-5,6-dihydropyrrolo[2,3-d]pyrimidin-4-yl)pyrimidin-2-amine" @default.
- NCIT_C158603 hasExactSynonym "Alpha-selective PI3K Inhibitor MEN1611" @default.
- NCIT_C158603 hasExactSynonym "CH 5132799" @default.
- NCIT_C158603 hasExactSynonym "CH-5132799" @default.
- NCIT_C158603 hasExactSynonym "CH5132799" @default.
- NCIT_C158603 hasExactSynonym "IZORLISIB" @default.
- NCIT_C158603 hasExactSynonym "Izorlisib" @default.
- NCIT_C158603 hasExactSynonym "MEN 1611" @default.
- NCIT_C158603 hasExactSynonym "MEN-1611" @default.
- NCIT_C158603 hasExactSynonym "MEN1611" @default.
- NCIT_C158603 hasExactSynonym "PA 799" @default.
- NCIT_C158603 hasExactSynonym "PA-799" @default.
- NCIT_C158603 hasExactSynonym "PA799" @default.
- NCIT_C158603 hasExactSynonym "PI3K-alpha Inhibitor MEN1611" @default.
- NCIT_C158603 hasExactSynonym "PI3Kalpha Inhibitor MEN1611" @default.
- NCIT_C158603 inSubset NCIT_C116977 @default.
- NCIT_C158603 inSubset NCIT_C116978 @default.
- NCIT_C158603 inSubset NCIT_C128784 @default.
- NCIT_C158603 inSubset NCIT_C157711 @default.
- NCIT_C158603 inSubset NCIT_C157712 @default.
- NCIT_C158603 inSubset NCIT_C176424 @default.
- NCIT_C158603 inSubset NCIT_C177537 @default.
- NCIT_C158603 inSubset NCIT_C63923 @default.
- NCIT_C158603 type Class @default.
- NCIT_C158603 isDefinedBy ncit.owl @default.
- NCIT_C158603 label "Izorlisib" @default.
- NCIT_C158603 subClassOf NCIT_C129824 @default.
- NCIT_C158603 subClassOf NCIT_C129825 @default.
- NCIT_C158603 subClassOf NCIT_C1404 @default.
- NCIT_C158603 subClassOf NCIT_C158603 @default.
- NCIT_C158603 subClassOf NCIT_C163758 @default.
- NCIT_C158603 subClassOf NCIT_C1742 @default.
- NCIT_C158603 subClassOf NCIT_C1908 @default.
- NCIT_C158603 subClassOf NCIT_C1909 @default.
- NCIT_C158603 subClassOf NCIT_C2152 @default.
- NCIT_C158603 subClassOf NCIT_C2189 @default.
- NCIT_C158603 subClassOf NCIT_C274 @default.
- NCIT_C158603 subClassOf NCIT_C471 @default.