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- NCIT_C158723 IAO_0000115 "An ophthalmic nanoemulsion consisting of the tartrate salt form of brimonidine, an imidazole derivative and selective alpha-2 adrenergic receptor agonist, with potential anti-inflammatory and vasoconstrictive activities. Upon ophthalmic instillation, brimonidine tartrate nanoemulsion OCU-300 reduces intraocular pressure by promoting the outflow and decreasing the production of aqueous humor and may reduce ocular erythema through direct vasoconstriction. Additionally, brimonidine may disrupt leukocyte extravasation into the ocular tissue, inhibit nociception and reduce inflammation associated with ocular graft-versus-host disease (oGvHD). The nanoemulsion formulation may enhance distribution of brimonidine to target tissues, thereby allowing more of the active drug to reach underlying ocular tissue." @default.
- NCIT_C158723 NCIT_A32 NCIT_C1909 @default.
- NCIT_C158723 NCIT_A6 NCIT_C65269 @default.
- NCIT_C158723 NCIT_NHC0 "C158723" @default.
- NCIT_C158723 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C158723 NCIT_P107 "Brimonidine Tartrate Nanoemulsion OCU-300" @default.
- NCIT_C158723 NCIT_P108 "Brimonidine Tartrate Nanoemulsion OCU-300" @default.
- NCIT_C158723 NCIT_P208 "CL950750" @default.
- NCIT_C158723 NCIT_P322 "CTRP" @default.
- NCIT_C158723 NCIT_P322 "GDC" @default.
- NCIT_C158723 NCIT_P329 "797485" @default.
- NCIT_C158723 NCIT_P330 "797485" @default.
- NCIT_C158723 NCIT_P375 "Brimonidine Tartrate Nanoemulsion OCU-300" @default.
- NCIT_C158723 NCIT_P399 "797485" @default.
- NCIT_C158723 normalizedInformationContent "100" @default.
- NCIT_C158723 referenceCount "1" @default.
- NCIT_C158723 hasExactSynonym "Brimonidine Tartrate Nanoemulsion OCU-300" @default.
- NCIT_C158723 hasExactSynonym "OCU 300" @default.
- NCIT_C158723 hasExactSynonym "OCU-300" @default.
- NCIT_C158723 hasExactSynonym "OCU300" @default.
- NCIT_C158723 inSubset NCIT_C116977 @default.
- NCIT_C158723 inSubset NCIT_C116978 @default.
- NCIT_C158723 inSubset NCIT_C157711 @default.
- NCIT_C158723 inSubset NCIT_C157712 @default.
- NCIT_C158723 inSubset NCIT_C176424 @default.
- NCIT_C158723 inSubset NCIT_C177537 @default.
- NCIT_C158723 type Class @default.
- NCIT_C158723 isDefinedBy ncit.owl @default.
- NCIT_C158723 label "Brimonidine Tartrate Nanoemulsion OCU-300" @default.
- NCIT_C158723 subClassOf NCIT_C158723 @default.
- NCIT_C158723 subClassOf NCIT_C1908 @default.
- NCIT_C158723 subClassOf NCIT_C1909 @default.
- NCIT_C158723 subClassOf NCIT_C29709 @default.
- NCIT_C158723 subClassOf NCIT_C29747 @default.
- NCIT_C158723 subClassOf NCIT_C78272 @default.
- NCIT_C158723 subClassOf NCIT_C87053 @default.