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- NCIT_C158733 IAO_0000115 "A radioimmunoconjugate consisting of an antibody directed against the immunosuppressive ligand programmed cell death-1 ligand 1 (PD-L1; cluster of differentiation 274; CD274), linked, via the chelator desferrioxamine (DFO), to the radioisotope zirconium Zr 89 (Zr89), with potential diagnostic properties upon positron emission tomography (PET) imaging. Upon administration, the antibody moiety of zirconium Zr 89-DFO-REGN3504 specifically targets and binds to PD-L1. Upon binding, the radioisotope moiety may be detected using PET, thereby allowing the imaging and quantification of PD-L1-expressing tumor cells. PD-L1, a transmembrane protein expressed on activated T-cells, is overexpressed in some cancer types and plays a significant role in immune evasion by tumor cells." @default.
- NCIT_C158733 NCIT_A7 NCIT_C96024 @default.
- NCIT_C158733 NCIT_NHC0 "C158733" @default.
- NCIT_C158733 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C158733 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C158733 NCIT_P107 "Zirconium Zr 89-DFO-REGN3504" @default.
- NCIT_C158733 NCIT_P108 "Zirconium Zr 89-DFO-REGN3504" @default.
- NCIT_C158733 NCIT_P208 "CL950702" @default.
- NCIT_C158733 NCIT_P322 "CTRP" @default.
- NCIT_C158733 NCIT_P329 "797339" @default.
- NCIT_C158733 NCIT_P330 "797339" @default.
- NCIT_C158733 NCIT_P399 "797339" @default.
- NCIT_C158733 normalizedInformationContent "100" @default.
- NCIT_C158733 referenceCount "1" @default.
- NCIT_C158733 hasExactSynonym "89Zr-DFO-REGN3504" @default.
- NCIT_C158733 hasExactSynonym "Zirconium Zr 89-DFO-REGN3504" @default.
- NCIT_C158733 inSubset NCIT_C116977 @default.
- NCIT_C158733 inSubset NCIT_C116978 @default.
- NCIT_C158733 inSubset NCIT_C176424 @default.
- NCIT_C158733 type Class @default.
- NCIT_C158733 isDefinedBy ncit.owl @default.
- NCIT_C158733 label "Zirconium Zr 89-DFO-REGN3504" @default.
- NCIT_C158733 subClassOf NCIT_C1446 @default.
- NCIT_C158733 subClassOf NCIT_C1511 @default.
- NCIT_C158733 subClassOf NCIT_C1512 @default.
- NCIT_C158733 subClassOf NCIT_C158733 @default.
- NCIT_C158733 subClassOf NCIT_C1908 @default.
- NCIT_C158733 subClassOf NCIT_C1909 @default.
- NCIT_C158733 subClassOf NCIT_C2124 @default.
- NCIT_C158733 subClassOf NCIT_C307 @default.
- NCIT_C158733 subClassOf NCIT_C308 @default.