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- NCIT_C158821 IAO_0000115 "A synthetic triazole antifungal agent, with activity against a variety of pathogenic fungi that can potentially be used against invasive pulmonary aspergillosis. Upon inhalation by nebulizer, opelconazole is delivered in high concentrations to the lungs and resides in the lung tissues for a long period of time with minimal systemic exposure. Opelconazole selectively binds to and inhibits the CYP450-dependent 14-alpha-sterol demethylase in fungi, thereby preventing the production of ergosterol, which is an essential constituent of the fungal cell membrane. This results in fungal cell lysis and inhibits fungal infection in the lungs." @default.
- NCIT_C158821 NCIT_NHC0 "C158821" @default.
- NCIT_C158821 NCIT_P106 "Organic Chemical" @default.
- NCIT_C158821 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C158821 NCIT_P107 "Opelconazole" @default.
- NCIT_C158821 NCIT_P108 "Opelconazole" @default.
- NCIT_C158821 NCIT_P208 "CL950891" @default.
- NCIT_C158821 NCIT_P210 "1931946-73-4" @default.
- NCIT_C158821 NCIT_P319 "45LU8Q6ASU" @default.
- NCIT_C158821 NCIT_P322 "CTRP" @default.
- NCIT_C158821 NCIT_P322 "FDA" @default.
- NCIT_C158821 NCIT_P329 "797368" @default.
- NCIT_C158821 NCIT_P330 "797368" @default.
- NCIT_C158821 NCIT_P399 "797368" @default.
- NCIT_C158821 normalizedInformationContent "100" @default.
- NCIT_C158821 referenceCount "1" @default.
- NCIT_C158821 hasExactSynonym "4-[4-(4-{[(3R,5R)-5-(2,4-Difluorophenyl)-5-(1H-1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy}-3-methylphenyl)piperazin-1-yl]-N-(4-fluorophenyl)benzamide" @default.
- NCIT_C158821 hasExactSynonym "Antifungal PC945" @default.
- NCIT_C158821 hasExactSynonym "Inhaled Antifungal PC945" @default.
- NCIT_C158821 hasExactSynonym "OPELCONAZOLE" @default.
- NCIT_C158821 hasExactSynonym "Opelconazole" @default.
- NCIT_C158821 hasExactSynonym "PC 945" @default.
- NCIT_C158821 hasExactSynonym "PC-945" @default.
- NCIT_C158821 hasExactSynonym "PC945" @default.
- NCIT_C158821 hasExactSynonym "Triazole Antifungal PC945" @default.
- NCIT_C158821 inSubset NCIT_C116977 @default.
- NCIT_C158821 inSubset NCIT_C116978 @default.
- NCIT_C158821 inSubset NCIT_C176424 @default.
- NCIT_C158821 inSubset NCIT_C63923 @default.
- NCIT_C158821 type Class @default.
- NCIT_C158821 isDefinedBy ncit.owl @default.
- NCIT_C158821 label "Opelconazole" @default.
- NCIT_C158821 subClassOf NCIT_C158821 @default.
- NCIT_C158821 subClassOf NCIT_C1908 @default.
- NCIT_C158821 subClassOf NCIT_C1909 @default.
- NCIT_C158821 subClassOf NCIT_C254 @default.
- NCIT_C158821 subClassOf NCIT_C514 @default.