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- NCIT_C158906 IAO_0000115 "The adipate salt form of itacitinib, an orally bioavailable inhibitor of Janus-associated kinase 1 (JAK1) with potential antineoplastic and immunomodulating activities. Upon oral administration, itacitinib selectively inhibits JAK-1, thereby inhibiting the phosphorylation of signal transducer and activator of transcription (STAT) proteins and the production of proinflammatory factors induced by other cytokines, including interleukin-23 (IL-23) and interleukin-6 (IL-6). The JAK-STAT pathway plays a key role in the signaling of many cytokines and growth factors and is involved in cellular proliferation, growth, hematopoiesis, and the immune response; JAK kinases may be upregulated in inflammatory diseases, myeloproliferative disorders, and various malignancies." @default.
- NCIT_C158906 NCIT_A32 NCIT_C1909 @default.
- NCIT_C158906 NCIT_A6 NCIT_C116855 @default.
- NCIT_C158906 NCIT_A7 NCIT_C28493 @default.
- NCIT_C158906 NCIT_NHC0 "C158906" @default.
- NCIT_C158906 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C158906 NCIT_P107 "Itacitinib Adipate" @default.
- NCIT_C158906 NCIT_P108 "Itacitinib Adipate" @default.
- NCIT_C158906 NCIT_P208 "CL950797" @default.
- NCIT_C158906 NCIT_P210 "1334302-63-4" @default.
- NCIT_C158906 NCIT_P319 "XZG407XE0Y" @default.
- NCIT_C158906 NCIT_P322 "CTRP" @default.
- NCIT_C158906 NCIT_P322 "FDA" @default.
- NCIT_C158906 NCIT_P322 "GDC" @default.
- NCIT_C158906 NCIT_P329 "740328" @default.
- NCIT_C158906 NCIT_P330 "740328" @default.
- NCIT_C158906 NCIT_P375 "Itacitinib Adipate" @default.
- NCIT_C158906 NCIT_P399 "740328" @default.
- NCIT_C158906 normalizedInformationContent "100" @default.
- NCIT_C158906 referenceCount "1" @default.
- NCIT_C158906 hasExactSynonym "INCB-039110 Adipate" @default.
- NCIT_C158906 hasExactSynonym "INCB039110 Adipate" @default.
- NCIT_C158906 hasExactSynonym "ITACITINIB ADIPATE" @default.
- NCIT_C158906 hasExactSynonym "Itacitinib Adipate" @default.
- NCIT_C158906 inSubset NCIT_C116977 @default.
- NCIT_C158906 inSubset NCIT_C116978 @default.
- NCIT_C158906 inSubset NCIT_C128784 @default.
- NCIT_C158906 inSubset NCIT_C157711 @default.
- NCIT_C158906 inSubset NCIT_C157712 @default.
- NCIT_C158906 inSubset NCIT_C176424 @default.
- NCIT_C158906 inSubset NCIT_C177537 @default.
- NCIT_C158906 inSubset NCIT_C63923 @default.
- NCIT_C158906 type Class @default.
- NCIT_C158906 isDefinedBy ncit.owl @default.
- NCIT_C158906 label "Itacitinib Adipate" @default.
- NCIT_C158906 subClassOf NCIT_C129824 @default.
- NCIT_C158906 subClassOf NCIT_C129825 @default.
- NCIT_C158906 subClassOf NCIT_C1404 @default.
- NCIT_C158906 subClassOf NCIT_C158906 @default.
- NCIT_C158906 subClassOf NCIT_C1908 @default.
- NCIT_C158906 subClassOf NCIT_C1909 @default.
- NCIT_C158906 subClassOf NCIT_C1967 @default.
- NCIT_C158906 subClassOf NCIT_C2189 @default.
- NCIT_C158906 subClassOf NCIT_C274 @default.
- NCIT_C158906 subClassOf NCIT_C308 @default.
- NCIT_C158906 subClassOf NCIT_C471 @default.
- NCIT_C158906 subClassOf NCIT_C574 @default.