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- NCIT_C158983 IAO_0000115 "A radiotracer composed of ECL1i (extracellular loop 1 inverso; d(LGTFLKC)), an allosteric peptidic modulator of CC chemokine receptor type 2 (CCR2), conjugated with 1,4,7,10-tetra-azacyclododecane-1,4,7,10-tetra-acetic acid (DOTA) and labeled with the radionuclide copper Cu 64, with potential imaging activity upon positron emission tomography (PET). Upon administration, the ECL1i moiety targets and allosterically binds to CCR2 expressing tumor cells. Upon PET imaging, the copper Cu 64 moiety can be visualized, thereby allowing the quantification of CCR2-expressing cells. CCR2, a G-protein coupled receptor expressed on the surface of monocytes and macrophages, stimulates the migration and infiltration of these cell types, and plays a significant role in angiogenesis, inflammation, tumor cell migration, and proliferation. Quantification of CCR2 may help predict chemotherapy resistance and identify early metastatic disease in certain cancers." @default.
- NCIT_C158983 NCIT_A7 NCIT_C101579 @default.
- NCIT_C158983 NCIT_NHC0 "C158983" @default.
- NCIT_C158983 NCIT_P106 "Indicator, Reagent, or Diagnostic Aid" @default.
- NCIT_C158983 NCIT_P107 "Copper Cu 64-DOTA-ECL1i" @default.
- NCIT_C158983 NCIT_P108 "Copper Cu 64-DOTA-ECL1i" @default.
- NCIT_C158983 NCIT_P208 "CL950986" @default.
- NCIT_C158983 NCIT_P322 "CTRP" @default.
- NCIT_C158983 NCIT_P329 "797547" @default.
- NCIT_C158983 NCIT_P330 "797547" @default.
- NCIT_C158983 NCIT_P399 "797547" @default.
- NCIT_C158983 normalizedInformationContent "100" @default.
- NCIT_C158983 referenceCount "1" @default.
- NCIT_C158983 hasExactSynonym "64Cu-DOTA-ECL1i" @default.
- NCIT_C158983 hasExactSynonym "64Cu-d(LGTFLKC)" @default.
- NCIT_C158983 hasExactSynonym "Copper Cu 64-DOTA-ECL1i" @default.
- NCIT_C158983 inSubset NCIT_C116977 @default.
- NCIT_C158983 inSubset NCIT_C116978 @default.
- NCIT_C158983 inSubset NCIT_C176424 @default.
- NCIT_C158983 type Class @default.
- NCIT_C158983 isDefinedBy ncit.owl @default.
- NCIT_C158983 label "Copper Cu 64-DOTA-ECL1i" @default.
- NCIT_C158983 subClassOf NCIT_C1446 @default.
- NCIT_C158983 subClassOf NCIT_C158983 @default.
- NCIT_C158983 subClassOf NCIT_C1908 @default.
- NCIT_C158983 subClassOf NCIT_C1909 @default.
- NCIT_C158983 subClassOf NCIT_C2124 @default.