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- NCIT_C159411 IAO_0000115 "A human, high-affinity, tetravalent monospecific agonistic monoclonal antibody targeting glucocorticoid-induced tumor necrosis factor receptor (GITR; tumor necrosis factor superfamily member 18; TNFRSF18; CD357), with potential immune checkpoint modulating activity. Upon administration, anti-GITR agonistic monoclonal antibody ASP1951 binds to and activates GITR, which is expressed on the cell surface of multiple types of T-lymphocytes. This induces both the activation and proliferation of tumor antigen-specific T-effector cells (Teffs), and suppresses the function of activated T-regulatory cells (Tregs), which may promote the elimination of tumor cells. GITR, a member of the TNF receptor superfamily and T-cell receptor co-stimulator, is expressed on the surface of multiple immune cell types, including Tregs, Teffs, B-cells, and natural killer (NK) cells. Inappropriately activated Tregs suppress both Teffs and T-cell receptor (TCR) signaling." @default.
- NCIT_C159411 NCIT_A32 NCIT_C1909 @default.
- NCIT_C159411 NCIT_A7 NCIT_C105568 @default.
- NCIT_C159411 NCIT_NHC0 "C159411" @default.
- NCIT_C159411 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C159411 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C159411 NCIT_P107 "Anti-GITR Agonistic Monoclonal Antibody ASP1951" @default.
- NCIT_C159411 NCIT_P108 "Anti-GITR Agonistic Monoclonal Antibody ASP1951" @default.
- NCIT_C159411 NCIT_P208 "CL951269" @default.
- NCIT_C159411 NCIT_P319 "F6WFM86G7J" @default.
- NCIT_C159411 NCIT_P322 "CTRP" @default.
- NCIT_C159411 NCIT_P322 "FDA" @default.
- NCIT_C159411 NCIT_P322 "GDC" @default.
- NCIT_C159411 NCIT_P329 "797644" @default.
- NCIT_C159411 NCIT_P330 "797644" @default.
- NCIT_C159411 NCIT_P375 "Anti-GITR Agonistic Monoclonal Antibody ASP1951" @default.
- NCIT_C159411 NCIT_P399 "797644" @default.
- NCIT_C159411 NCIT_R124 NCIT_C17710 @default.
- NCIT_C159411 NCIT_R124 NCIT_C17828 @default.
- NCIT_C159411 NCIT_R124 NCIT_C18219 @default.
- NCIT_C159411 NCIT_R124 NCIT_C19986 @default.
- NCIT_C159411 NCIT_R124 NCIT_C40474 @default.
- NCIT_C159411 normalizedInformationContent "100" @default.
- NCIT_C159411 referenceCount "1" @default.
- NCIT_C159411 hasExactSynonym "ASP 1951" @default.
- NCIT_C159411 hasExactSynonym "ASP-1951" @default.
- NCIT_C159411 hasExactSynonym "ASP1951" @default.
- NCIT_C159411 hasExactSynonym "Anti-GITR Agonistic Monoclonal Antibody ASP1951" @default.
- NCIT_C159411 hasExactSynonym "Anti-GITR Agonistic Monoclonal Antibody PTZ-522" @default.
- NCIT_C159411 hasExactSynonym "PTZ 522" @default.
- NCIT_C159411 hasExactSynonym "PTZ-522" @default.
- NCIT_C159411 hasExactSynonym "PTZ522" @default.
- NCIT_C159411 inSubset NCIT_C116977 @default.
- NCIT_C159411 inSubset NCIT_C116978 @default.
- NCIT_C159411 inSubset NCIT_C128784 @default.
- NCIT_C159411 inSubset NCIT_C157711 @default.
- NCIT_C159411 inSubset NCIT_C157712 @default.
- NCIT_C159411 inSubset NCIT_C176424 @default.
- NCIT_C159411 inSubset NCIT_C177537 @default.
- NCIT_C159411 inSubset NCIT_C63923 @default.
- NCIT_C159411 type Class @default.
- NCIT_C159411 isDefinedBy ncit.owl @default.
- NCIT_C159411 label "Anti-GITR Agonistic Monoclonal Antibody ASP1951" @default.
- NCIT_C159411 subClassOf NCIT_C128058 @default.
- NCIT_C159411 subClassOf NCIT_C129820 @default.
- NCIT_C159411 subClassOf NCIT_C129821 @default.
- NCIT_C159411 subClassOf NCIT_C129822 @default.
- NCIT_C159411 subClassOf NCIT_C141144 @default.
- NCIT_C159411 subClassOf NCIT_C159411 @default.
- NCIT_C159411 subClassOf NCIT_C1908 @default.
- NCIT_C159411 subClassOf NCIT_C1909 @default.
- NCIT_C159411 subClassOf NCIT_C201119 @default.
- NCIT_C159411 subClassOf NCIT_C20401 @default.
- NCIT_C159411 subClassOf NCIT_C274 @default.
- NCIT_C159411 subClassOf NCIT_C307 @default.
- NCIT_C159411 subClassOf NCIT_C308 @default.