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- NCIT_C159496 IAO_0000115 "An orally bioavailable inhibitor of histone deacetylase (HDAC) type 8 (HDAC8; HDAC-8), with potential antineoplastic activity. Upon administration, NBM-BMX targets and inhibits the activity of HDAC8. This results in an accumulation of highly acetylated chromatin histones, chromatin remodeling, and selective transcription of tumor suppressor genes, ultimately promoting cell-cycle arrest and induction of tumor cell apoptosis. HDAC8, a class 1 histone deacetylase, plays a key role in transcriptional regulation and cell cycle progression. Aberrant expression of HDAC8 or deregulated interactions with transcription factors may contribute to tumorigenesis. Isotype-selective HDAC inhibitors may be associated with fewer adverse effects compared to pan-HDAC inhibitors." @default.
- NCIT_C159496 NCIT_A32 NCIT_C1909 @default.
- NCIT_C159496 NCIT_A7 NCIT_C16682 @default.
- NCIT_C159496 NCIT_NHC0 "C159496" @default.
- NCIT_C159496 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C159496 NCIT_P108 "HDAC8 Inhibitor NBM-BMX" @default.
- NCIT_C159496 NCIT_P208 "CL951454" @default.
- NCIT_C159496 NCIT_P322 "GDC" @default.
- NCIT_C159496 NCIT_P329 "797563" @default.
- NCIT_C159496 NCIT_P330 "797563" @default.
- NCIT_C159496 NCIT_P375 "HDAC8 Inhibitor NBM-BMX" @default.
- NCIT_C159496 NCIT_P399 "797563" @default.
- NCIT_C159496 normalizedInformationContent "100" @default.
- NCIT_C159496 referenceCount "1" @default.
- NCIT_C159496 hasExactSynonym "HDAC8 Inhibitor NBM-BMX" @default.
- NCIT_C159496 hasExactSynonym "HDAC8i NBM-BMX" @default.
- NCIT_C159496 hasExactSynonym "NBM BMX" @default.
- NCIT_C159496 hasExactSynonym "NBM-BMX" @default.
- NCIT_C159496 hasExactSynonym "NBMBMX" @default.
- NCIT_C159496 inSubset NCIT_C128784 @default.
- NCIT_C159496 inSubset NCIT_C157711 @default.
- NCIT_C159496 inSubset NCIT_C157712 @default.
- NCIT_C159496 inSubset NCIT_C176424 @default.
- NCIT_C159496 inSubset NCIT_C177537 @default.
- NCIT_C159496 type Class @default.
- NCIT_C159496 isDefinedBy ncit.owl @default.
- NCIT_C159496 label "HDAC8 Inhibitor NBM-BMX" @default.
- NCIT_C159496 subClassOf NCIT_C129824 @default.
- NCIT_C159496 subClassOf NCIT_C129825 @default.
- NCIT_C159496 subClassOf NCIT_C159496 @default.
- NCIT_C159496 subClassOf NCIT_C163758 @default.
- NCIT_C159496 subClassOf NCIT_C1908 @default.
- NCIT_C159496 subClassOf NCIT_C1909 @default.
- NCIT_C159496 subClassOf NCIT_C1946 @default.
- NCIT_C159496 subClassOf NCIT_C2189 @default.
- NCIT_C159496 subClassOf NCIT_C274 @default.
- NCIT_C159496 subClassOf NCIT_C471 @default.