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- NCIT_C159530 IAO_0000115 "An Fc-engineered bispecific antibody directed against the human negative immunoregulatory checkpoint receptors cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4) and lymphocyte activation gene 3 protein (LAG3; LAG-3; CD223), with potential immune checkpoint inhibitory and antineoplastic activities. Upon administration, bavunalimab targets and binds to both CTLA-4 and LAG-3 expressed on T-cells in the tumor microenvironment (TME). Both CTLA-4 and LAG-3 are inhibitory receptors and members of the immunoglobulin superfamily (IgSF); they are overexpressed by regulatory T-cells (Tregs) in the TME where they downregulate T-cell activation and proliferation. Dual checkpoint blockade of CTLA-4 and LAG-3 with XmAb22841 may enhance T-cell activation and proliferation more than the blockade of either immune checkpoint receptor alone. The engineered Fc domain increases the stability and half-life of the antibody." @default.
- NCIT_C159530 NCIT_A32 NCIT_C1909 @default.
- NCIT_C159530 NCIT_A7 NCIT_C17489 @default.
- NCIT_C159530 NCIT_NHC0 "C159530" @default.
- NCIT_C159530 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C159530 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C159530 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C159530 NCIT_P107 "Bavunalimab" @default.
- NCIT_C159530 NCIT_P108 "Pavunalimab" @default.
- NCIT_C159530 NCIT_P208 "CL951426" @default.
- NCIT_C159530 NCIT_P210 "2329669-78-3" @default.
- NCIT_C159530 NCIT_P319 "3PT70X17VS" @default.
- NCIT_C159530 NCIT_P322 "CTRP" @default.
- NCIT_C159530 NCIT_P322 "FDA" @default.
- NCIT_C159530 NCIT_P322 "GDC" @default.
- NCIT_C159530 NCIT_P329 "797814" @default.
- NCIT_C159530 NCIT_P330 "797814" @default.
- NCIT_C159530 NCIT_P375 "Anti-CTLA-4/LAG-3 Bispecific Antibody XmAb22841" @default.
- NCIT_C159530 NCIT_P399 "797814" @default.
- NCIT_C159530 NCIT_R124 NCIT_C17710 @default.
- NCIT_C159530 NCIT_R124 NCIT_C17828 @default.
- NCIT_C159530 NCIT_R124 NCIT_C18219 @default.
- NCIT_C159530 NCIT_R124 NCIT_C19986 @default.
- NCIT_C159530 NCIT_R124 NCIT_C40474 @default.
- NCIT_C159530 normalizedInformationContent "100" @default.
- NCIT_C159530 referenceCount "1" @default.
- NCIT_C159530 hasExactSynonym "Anti-CTLA-4/Anti-LAG-3 Bispecific Monoclonal Antibody XmAb22841" @default.
- NCIT_C159530 hasExactSynonym "Anti-CTLA-4/LAG-3 Bispecific Antibody XmAb22841" @default.
- NCIT_C159530 hasExactSynonym "BAVUNALIMAB" @default.
- NCIT_C159530 hasExactSynonym "Bavunalimab" @default.
- NCIT_C159530 hasExactSynonym "CTLA-4 x LAG-3 Bispecific Antibody XmAb22841" @default.
- NCIT_C159530 hasExactSynonym "Pavunalimab" @default.
- NCIT_C159530 hasExactSynonym "XmAb 22841" @default.
- NCIT_C159530 hasExactSynonym "XmAb-22841" @default.
- NCIT_C159530 hasExactSynonym "XmAb22841" @default.
- NCIT_C159530 inSubset NCIT_C116977 @default.
- NCIT_C159530 inSubset NCIT_C116978 @default.
- NCIT_C159530 inSubset NCIT_C128784 @default.
- NCIT_C159530 inSubset NCIT_C157711 @default.
- NCIT_C159530 inSubset NCIT_C157712 @default.
- NCIT_C159530 inSubset NCIT_C176424 @default.
- NCIT_C159530 inSubset NCIT_C177537 @default.
- NCIT_C159530 inSubset NCIT_C63923 @default.
- NCIT_C159530 type Class @default.
- NCIT_C159530 isDefinedBy ncit.owl @default.
- NCIT_C159530 label "Pavunalimab" @default.
- NCIT_C159530 subClassOf NCIT_C128036 @default.
- NCIT_C159530 subClassOf NCIT_C129821 @default.
- NCIT_C159530 subClassOf NCIT_C129822 @default.
- NCIT_C159530 subClassOf NCIT_C134305 @default.
- NCIT_C159530 subClassOf NCIT_C141144 @default.
- NCIT_C159530 subClassOf NCIT_C143250 @default.
- NCIT_C159530 subClassOf NCIT_C1454 @default.
- NCIT_C159530 subClassOf NCIT_C159530 @default.
- NCIT_C159530 subClassOf NCIT_C163758 @default.
- NCIT_C159530 subClassOf NCIT_C1908 @default.
- NCIT_C159530 subClassOf NCIT_C1909 @default.
- NCIT_C159530 subClassOf NCIT_C191738 @default.
- NCIT_C159530 subClassOf NCIT_C200483 @default.
- NCIT_C159530 subClassOf NCIT_C20401 @default.
- NCIT_C159530 subClassOf NCIT_C274 @default.
- NCIT_C159530 subClassOf NCIT_C28227 @default.
- NCIT_C159530 subClassOf NCIT_C307 @default.
- NCIT_C159530 subClassOf NCIT_C308 @default.