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- NCIT_C159531 IAO_0000115 "A topically bioavailable small molecule inhibitor of serine/threonine-protein kinase B-raf (BRAF) protein with potential chemoprotective activity. Upon topical administration, BRAF inhibitor LUT014 targets and binds BRAF and, through the paradoxical effect of BRAF inhibition, induces mitogen-activated protein kinase (MAPK) signaling, which leads to the proliferation and migration of healthy human keratinocytes. This decreases dermal toxicities associated with epidermal growth factor (EGFR) inhibitor therapy. BRAF, a member of the raf family of serine/threonine protein kinases, plays a role in the regulation of MAPK/extracellular signal-regulated kinase (ERK) signaling pathways." @default.
- NCIT_C159531 NCIT_A7 NCIT_C17476 @default.
- NCIT_C159531 NCIT_NHC0 "C159531" @default.
- NCIT_C159531 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C159531 NCIT_P107 "BRAF Inhibitor LUT014" @default.
- NCIT_C159531 NCIT_P108 "BRAF Inhibitor LUT014" @default.
- NCIT_C159531 NCIT_P208 "CL951427" @default.
- NCIT_C159531 NCIT_P319 "T4E4I523RY" @default.
- NCIT_C159531 NCIT_P322 "CTRP" @default.
- NCIT_C159531 NCIT_P322 "FDA" @default.
- NCIT_C159531 NCIT_P329 "797806" @default.
- NCIT_C159531 NCIT_P330 "797806" @default.
- NCIT_C159531 NCIT_P399 "797806" @default.
- NCIT_C159531 normalizedInformationContent "100" @default.
- NCIT_C159531 referenceCount "1" @default.
- NCIT_C159531 hasExactSynonym "BRAF Inhibitor LUT014" @default.
- NCIT_C159531 hasExactSynonym "LUT 014" @default.
- NCIT_C159531 hasExactSynonym "LUT-014" @default.
- NCIT_C159531 hasExactSynonym "LUT014" @default.
- NCIT_C159531 inSubset NCIT_C116977 @default.
- NCIT_C159531 inSubset NCIT_C116978 @default.
- NCIT_C159531 inSubset NCIT_C128784 @default.
- NCIT_C159531 inSubset NCIT_C176424 @default.
- NCIT_C159531 inSubset NCIT_C63923 @default.
- NCIT_C159531 type Class @default.
- NCIT_C159531 isDefinedBy ncit.owl @default.
- NCIT_C159531 label "BRAF Inhibitor LUT014" @default.
- NCIT_C159531 subClassOf NCIT_C129824 @default.
- NCIT_C159531 subClassOf NCIT_C129825 @default.
- NCIT_C159531 subClassOf NCIT_C1404 @default.
- NCIT_C159531 subClassOf NCIT_C155322 @default.
- NCIT_C159531 subClassOf NCIT_C159531 @default.
- NCIT_C159531 subClassOf NCIT_C163758 @default.
- NCIT_C159531 subClassOf NCIT_C1908 @default.
- NCIT_C159531 subClassOf NCIT_C1909 @default.
- NCIT_C159531 subClassOf NCIT_C2189 @default.
- NCIT_C159531 subClassOf NCIT_C2336 @default.
- NCIT_C159531 subClassOf NCIT_C274 @default.
- NCIT_C159531 subClassOf NCIT_C471 @default.
- NCIT_C159531 subClassOf NCIT_C61074 @default.