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- NCIT_C159541 IAO_0000115 "A humanized, immunoglobulin G4 (IgG4), bispecific monoclonal antibody against both the activated coagulation factor IX (FIXa) and factor X (FX) that can be used for the treatment of hemophilia A (HA). Upon administration, emicizumab targets and binds to both the FIXa and to FX, thereby bridging FIXa and FX, activating FX, and allowing for the activation and continuation of the coagulation cascade. FX is normally activated by coagulation factor VIII (FVIII); FVIII is missing in HA patients." @default.
- NCIT_C159541 NCIT_NHC0 "C159541" @default.
- NCIT_C159541 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C159541 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C159541 NCIT_P107 "Emicizumab" @default.
- NCIT_C159541 NCIT_P108 "Emicizumab" @default.
- NCIT_C159541 NCIT_P207 "C4278463" @default.
- NCIT_C159541 NCIT_P210 "1610943-06-0" @default.
- NCIT_C159541 NCIT_P302 "prophylaxis to prevent or reduce the frequency of bleeding episodes in adult and pediatric patients (ages newborn and older) with hemophilia A (congenital factor VIII deficiency) with or without factor VIII (FVIII) inhibitors" @default.
- NCIT_C159541 NCIT_P319 "7NL2E3F6K3" @default.
- NCIT_C159541 NCIT_P322 "CTRP" @default.
- NCIT_C159541 NCIT_P322 "FDA" @default.
- NCIT_C159541 NCIT_R124 NCIT_C17710 @default.
- NCIT_C159541 NCIT_R124 NCIT_C17828 @default.
- NCIT_C159541 NCIT_R124 NCIT_C18219 @default.
- NCIT_C159541 NCIT_R124 NCIT_C19986 @default.
- NCIT_C159541 NCIT_R124 NCIT_C40474 @default.
- NCIT_C159541 normalizedInformationContent "100" @default.
- NCIT_C159541 referenceCount "1" @default.
- NCIT_C159541 hasExactSynonym "ACE910" @default.
- NCIT_C159541 hasExactSynonym "EMICIZUMAB" @default.
- NCIT_C159541 hasExactSynonym "Emicizumab" @default.
- NCIT_C159541 hasExactSynonym "Emicizumab-kxwh" @default.
- NCIT_C159541 hasExactSynonym "Hemlibra" @default.
- NCIT_C159541 hasExactSynonym "Immunoglobulin G4-kappa, Bispecific, Anti-(Homo sapiens F9a (Activated Coagulation Factor F9, Activated Coagulation Factor IX) and Anti-(Homo sapiens F10 (Coagulation Factor 10, Coagulation Factor X)), Humanized Monoclonal Antibody" @default.
- NCIT_C159541 inSubset NCIT_C116977 @default.
- NCIT_C159541 inSubset NCIT_C116978 @default.
- NCIT_C159541 inSubset NCIT_C63923 @default.
- NCIT_C159541 type Class @default.
- NCIT_C159541 isDefinedBy ncit.owl @default.
- NCIT_C159541 label "Emicizumab" @default.
- NCIT_C159541 subClassOf NCIT_C159541 @default.
- NCIT_C159541 subClassOf NCIT_C1908 @default.
- NCIT_C159541 subClassOf NCIT_C1909 @default.
- NCIT_C159541 subClassOf NCIT_C20401 @default.
- NCIT_C159541 subClassOf NCIT_C307 @default.
- NCIT_C159541 subClassOf NCIT_C308 @default.