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- NCIT_C159599 IAO_0000115 "An oncolytic adenoviral vector, enadenotucirev (EnAd), that expresses a full-length agonistic anti-CD40 monoclonal antibody, with potential immunomodulating and antineoplastic activities. Upon intratumoral administration of NG-350A, enadenotucirev specifically infects and replicates in tumor cells and not in normal, noncancerous tissue, and selectively expresses the agonistic anti-CD40 antibody. The locally expressed anti-CD40 antibody targets and binds to CD40 on a variety of immune cells, including B-cells, T-cells and dendritic cells (DCs) in the tumor microenvironment (TME). This induces CD40-dependent signaling pathways, which activates these immune cells and induces a cytotoxic T-lymphocyte (CTL)-mediated antitumor immune response and leads to tumor cell death. CD40, a cell surface receptor and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on various immune cells and plays a key role in the activation of the immune system." @default.
- NCIT_C159599 NCIT_A32 NCIT_C1909 @default.
- NCIT_C159599 NCIT_A7 NCIT_C17281 @default.
- NCIT_C159599 NCIT_NHC0 "C159599" @default.
- NCIT_C159599 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C159599 NCIT_P107 "Enadenotucirev-expressing Anti-CD40 Agonistic Monoclonal Antibody NG-350A" @default.
- NCIT_C159599 NCIT_P108 "Enadenotucirev-expressing Anti-CD40 Agonistic Monoclonal Antibody NG-350A" @default.
- NCIT_C159599 NCIT_P208 "CL951598" @default.
- NCIT_C159599 NCIT_P322 "CTRP" @default.
- NCIT_C159599 NCIT_P322 "GDC" @default.
- NCIT_C159599 NCIT_P329 "797804" @default.
- NCIT_C159599 NCIT_P330 "797804" @default.
- NCIT_C159599 NCIT_P375 "Enadenotucirev-expressing Anti-CD40 Agonistic Monoclonal Antibody NG-350A" @default.
- NCIT_C159599 NCIT_P399 "797804" @default.
- NCIT_C159599 normalizedInformationContent "100" @default.
- NCIT_C159599 referenceCount "1" @default.
- NCIT_C159599 hasExactSynonym "Enadenotucirev-expressing Anti-CD40 Agonistic Monoclonal Antibody NG-350A" @default.
- NCIT_C159599 hasExactSynonym "NG 350A" @default.
- NCIT_C159599 hasExactSynonym "NG-350A" @default.
- NCIT_C159599 hasExactSynonym "NG350A" @default.
- NCIT_C159599 hasExactSynonym "Oncolytic Adenoviral Vector Expressing Anti-CD40 Antibody NG-350A" @default.
- NCIT_C159599 hasExactSynonym "Oncolytic Adenoviral Vector-expressing Anti-CD40 Agonistic Antibody NG-350A" @default.
- NCIT_C159599 inSubset NCIT_C116977 @default.
- NCIT_C159599 inSubset NCIT_C116978 @default.
- NCIT_C159599 inSubset NCIT_C128784 @default.
- NCIT_C159599 inSubset NCIT_C157711 @default.
- NCIT_C159599 inSubset NCIT_C157712 @default.
- NCIT_C159599 inSubset NCIT_C176424 @default.
- NCIT_C159599 inSubset NCIT_C177537 @default.
- NCIT_C159599 type Class @default.
- NCIT_C159599 isDefinedBy ncit.owl @default.
- NCIT_C159599 label "Enadenotucirev-expressing Anti-CD40 Agonistic Monoclonal Antibody NG-350A" @default.
- NCIT_C159599 subClassOf NCIT_C129821 @default.
- NCIT_C159599 subClassOf NCIT_C159599 @default.
- NCIT_C159599 subClassOf NCIT_C1908 @default.
- NCIT_C159599 subClassOf NCIT_C1909 @default.
- NCIT_C159599 subClassOf NCIT_C274 @default.
- NCIT_C159599 subClassOf NCIT_C307 @default.
- NCIT_C159599 subClassOf NCIT_C308 @default.
- NCIT_C159599 subClassOf NCIT_C717 @default.