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- NCIT_C159600 IAO_0000115 "A humanized immunoglobulin G2 (IgG2) monoclonal antibody targeting the human cell surface antigen CD47, with potential phagocytosis-inducing and antineoplastic activities. Upon administration, anti-CD47 monoclonal antibody AO-176 preferentially binds to CD47 on tumor cells because it exhibits enhanced binding at the acidic pH found in the tumor microenvironment (TME). This blocks the interaction of CD47 with signal regulatory protein alpha (SIRPalpha), an inhibitory protein expressed on macrophages and dendritic cells (DCs), which prevents CD47/SIRPalpha-mediated signaling and abrogates the CD47/SIRPalpha-mediated inhibition of phagocytosis. This induces pro-phagocytic signaling mediated by the binding of calreticulin (CRT), which is specifically expressed on the surface of tumor cells, to low-density lipoprotein (LDL) receptor-related protein (LRP), expressed on macrophages, which results in macrophage activation and the specific phagocytosis of tumor cells. Additionally, blocking CD47 signaling activates both an anti-tumor T-lymphocyte immune response and T-cell-mediated killing of CD47-expressing tumor cells. In addition, AO-176 induces immunogenic cell death (ICD) and releases damage-associated molecular patterns (DAMPs) from tumor cells, thereby further stimulating immune responses. AO-176 is also able to induce direct cytotoxic cell death by a cell autonomous mechanism. CD47, also called integrin-associated protein (IAP), is a tumor-associated antigen (TAA) expressed on normal, healthy hematopoietic stem cells (HSCs) and overexpressed on the surface of a variety of cancer cells. Expression of CD47, and its interaction with SIRPalpha, leads to the inhibition of macrophage activation and protects cancer cells from phagocytosis, which allows cancer cells to proliferate." @default.
- NCIT_C159600 NCIT_A32 NCIT_C1909 @default.
- NCIT_C159600 NCIT_A7 NCIT_C25795 @default.
- NCIT_C159600 NCIT_NHC0 "C159600" @default.
- NCIT_C159600 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C159600 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C159600 NCIT_P107 "Anti-CD47 Monoclonal Antibody AO-176" @default.
- NCIT_C159600 NCIT_P108 "Anti-CD47 Monoclonal Antibody AO-176" @default.
- NCIT_C159600 NCIT_P208 "CL951599" @default.
- NCIT_C159600 NCIT_P322 "CTRP" @default.
- NCIT_C159600 NCIT_P322 "GDC" @default.
- NCIT_C159600 NCIT_P329 "797803" @default.
- NCIT_C159600 NCIT_P330 "797803" @default.
- NCIT_C159600 NCIT_P375 "Anti-CD47 Monoclonal Antibody AO-176" @default.
- NCIT_C159600 NCIT_P399 "797803" @default.
- NCIT_C159600 NCIT_R124 NCIT_C17710 @default.
- NCIT_C159600 NCIT_R124 NCIT_C17828 @default.
- NCIT_C159600 NCIT_R124 NCIT_C18219 @default.
- NCIT_C159600 NCIT_R124 NCIT_C19986 @default.
- NCIT_C159600 NCIT_R124 NCIT_C40474 @default.
- NCIT_C159600 normalizedInformationContent "100" @default.
- NCIT_C159600 referenceCount "1" @default.
- NCIT_C159600 hasExactSynonym "AO 176" @default.
- NCIT_C159600 hasExactSynonym "AO-176" @default.
- NCIT_C159600 hasExactSynonym "AO176" @default.
- NCIT_C159600 hasExactSynonym "Anti-CD47 Monoclonal Antibody AO-176" @default.
- NCIT_C159600 inSubset NCIT_C116977 @default.
- NCIT_C159600 inSubset NCIT_C116978 @default.
- NCIT_C159600 inSubset NCIT_C128784 @default.
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- NCIT_C159600 type Class @default.
- NCIT_C159600 isDefinedBy ncit.owl @default.
- NCIT_C159600 label "Anti-CD47 Monoclonal Antibody AO-176" @default.
- NCIT_C159600 subClassOf B22f7ab7b5213c04ebad12bc8732b57be @default.
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- NCIT_C159600 subClassOf NCIT_C163758 @default.
- NCIT_C159600 subClassOf NCIT_C1908 @default.
- NCIT_C159600 subClassOf NCIT_C1909 @default.
- NCIT_C159600 subClassOf NCIT_C192655 @default.
- NCIT_C159600 subClassOf NCIT_C20401 @default.
- NCIT_C159600 subClassOf NCIT_C274 @default.
- NCIT_C159600 subClassOf NCIT_C307 @default.
- NCIT_C159600 subClassOf NCIT_C308 @default.