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- NCIT_C159652 IAO_0000115 "A short half-life bispecific T-cell engager (BiTE) antibody composed of two single-chain variable fragments (scFv), one directed against the tumor-associated antigen (TAA) human B-cell maturation antigen (BCMA; TNFRSF17), fused to one that is directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating and antineoplastic activities. Upon administration of pacanalotamab, this bispecific antibody binds to both CD3 on cytotoxic T-lymphocytes (CTLs) and BCMA found on BCMA-expressing tumor cells. This activates and redirects CTLs to BCMA-expressing tumor cells, which results in the CTL-mediated cell death of BCMA-expressing tumor cells. BCMA, a member of the tumor necrosis factor receptor superfamily that is specifically overexpressed on malignant plasma cells, plays a key role in promoting plasma cell survival." @default.
- NCIT_C159652 NCIT_A32 NCIT_C1909 @default.
- NCIT_C159652 NCIT_A7 NCIT_C97848 @default.
- NCIT_C159652 NCIT_NHC0 "C159652" @default.
- NCIT_C159652 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C159652 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C159652 NCIT_P107 "Pacanalotamab" @default.
- NCIT_C159652 NCIT_P108 "Pacanalotamab" @default.
- NCIT_C159652 NCIT_P208 "CL951538" @default.
- NCIT_C159652 NCIT_P210 "2251756-52-0" @default.
- NCIT_C159652 NCIT_P319 "102VUR9WQE" @default.
- NCIT_C159652 NCIT_P322 "CTRP" @default.
- NCIT_C159652 NCIT_P322 "FDA" @default.
- NCIT_C159652 NCIT_P322 "GDC" @default.
- NCIT_C159652 NCIT_P329 "801291" @default.
- NCIT_C159652 NCIT_P330 "801291" @default.
- NCIT_C159652 NCIT_P375 "Anti-BCMA/CD3 BiTE Antibody AMG 420" @default.
- NCIT_C159652 NCIT_P399 "801291" @default.
- NCIT_C159652 NCIT_R124 NCIT_C17710 @default.
- NCIT_C159652 NCIT_R124 NCIT_C17828 @default.
- NCIT_C159652 NCIT_R124 NCIT_C18219 @default.
- NCIT_C159652 NCIT_R124 NCIT_C19986 @default.
- NCIT_C159652 NCIT_R124 NCIT_C40474 @default.
- NCIT_C159652 normalizedInformationContent "100" @default.
- NCIT_C159652 referenceCount "1" @default.
- NCIT_C159652 hasExactSynonym "AMG 420" @default.
- NCIT_C159652 hasExactSynonym "AMG-420" @default.
- NCIT_C159652 hasExactSynonym "AMG420" @default.
- NCIT_C159652 hasExactSynonym "Anti-BCMA x Anti-CD3 BiTE AMG 420" @default.
- NCIT_C159652 hasExactSynonym "Anti-BCMA/CD3 BiTE Antibody AMG 420" @default.
- NCIT_C159652 hasExactSynonym "BCMA/CD3-directed Bispecific T-cell Engager Antibody AMG 420" @default.
- NCIT_C159652 hasExactSynonym "BI 836909" @default.
- NCIT_C159652 hasExactSynonym "BI-836909" @default.
- NCIT_C159652 hasExactSynonym "BI836909" @default.
- NCIT_C159652 hasExactSynonym "BiTE Antibody AMG 420" @default.
- NCIT_C159652 hasExactSynonym "Bispecific T-cell Engager Antibody AMG 420" @default.
- NCIT_C159652 hasExactSynonym "PACANALOTAMAB" @default.
- NCIT_C159652 hasExactSynonym "Pacanalotamab" @default.
- NCIT_C159652 inSubset NCIT_C116977 @default.
- NCIT_C159652 inSubset NCIT_C116978 @default.
- NCIT_C159652 inSubset NCIT_C128784 @default.
- NCIT_C159652 inSubset NCIT_C157711 @default.
- NCIT_C159652 inSubset NCIT_C157712 @default.
- NCIT_C159652 inSubset NCIT_C176424 @default.
- NCIT_C159652 inSubset NCIT_C177537 @default.
- NCIT_C159652 inSubset NCIT_C63923 @default.
- NCIT_C159652 type Class @default.
- NCIT_C159652 isDefinedBy ncit.owl @default.
- NCIT_C159652 label "Pacanalotamab" @default.
- NCIT_C159652 subClassOf NCIT_C112883 @default.
- NCIT_C159652 subClassOf NCIT_C129821 @default.
- NCIT_C159652 subClassOf NCIT_C129822 @default.
- NCIT_C159652 subClassOf NCIT_C1454 @default.
- NCIT_C159652 subClassOf NCIT_C159652 @default.
- NCIT_C159652 subClassOf NCIT_C163758 @default.
- NCIT_C159652 subClassOf NCIT_C181111 @default.
- NCIT_C159652 subClassOf NCIT_C181113 @default.
- NCIT_C159652 subClassOf NCIT_C181114 @default.
- NCIT_C159652 subClassOf NCIT_C1908 @default.
- NCIT_C159652 subClassOf NCIT_C1909 @default.
- NCIT_C159652 subClassOf NCIT_C201282 @default.
- NCIT_C159652 subClassOf NCIT_C20401 @default.
- NCIT_C159652 subClassOf NCIT_C274 @default.
- NCIT_C159652 subClassOf NCIT_C28227 @default.
- NCIT_C159652 subClassOf NCIT_C307 @default.
- NCIT_C159652 subClassOf NCIT_C308 @default.