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- NCIT_C159764 IAO_0000115 "A fully human immunoglobulin G1 (IgG1) antibody directed against the human T-cell-expressed receptor cytotoxic T-lymphocyte-associated antigen 4 (CTLA4; CTLA-4), with potential immune checkpoint inhibitory and antineoplastic activities. Upon intravenous administration, anti-CTLA-4 monoclonal antibody REGN4659 targets and binds to CTLA-4 expressed on T-cells and inhibits the CTLA-4-mediated downregulation of T-cell activation. This leads to a cytotoxic T-lymphocyte (CTL)-mediated immune response against cancer cells. CTLA-4, an inhibitory receptor and member of the immunoglobulin superfamily (IgSF), plays a key role in the downregulation of the immune system." @default.
- NCIT_C159764 NCIT_A32 NCIT_C1909 @default.
- NCIT_C159764 NCIT_A7 NCIT_C17489 @default.
- NCIT_C159764 NCIT_NHC0 "C159764" @default.
- NCIT_C159764 NCIT_P106 "Amino Acid, Peptide, or Protein" @default.
- NCIT_C159764 NCIT_P106 "Immunologic Factor" @default.
- NCIT_C159764 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C159764 NCIT_P107 "Anti-CTLA-4 Monoclonal Antibody REGN4659" @default.
- NCIT_C159764 NCIT_P108 "Anti-CTLA-4 Monoclonal Antibody REGN4659" @default.
- NCIT_C159764 NCIT_P208 "CL951623" @default.
- NCIT_C159764 NCIT_P319 "6CGQ1X5Y6V" @default.
- NCIT_C159764 NCIT_P322 "CTRP" @default.
- NCIT_C159764 NCIT_P322 "FDA" @default.
- NCIT_C159764 NCIT_P322 "GDC" @default.
- NCIT_C159764 NCIT_P329 "797920" @default.
- NCIT_C159764 NCIT_P330 "797920" @default.
- NCIT_C159764 NCIT_P375 "Anti-CTLA-4 Monoclonal Antibody REGN4659" @default.
- NCIT_C159764 NCIT_P399 "797920" @default.
- NCIT_C159764 NCIT_R124 NCIT_C17710 @default.
- NCIT_C159764 NCIT_R124 NCIT_C17828 @default.
- NCIT_C159764 NCIT_R124 NCIT_C18219 @default.
- NCIT_C159764 NCIT_R124 NCIT_C19986 @default.
- NCIT_C159764 NCIT_R124 NCIT_C40474 @default.
- NCIT_C159764 normalizedInformationContent "100" @default.
- NCIT_C159764 referenceCount "1" @default.
- NCIT_C159764 hasExactSynonym "Anti-CTLA-4 Monoclonal Antibody REGN4659" @default.
- NCIT_C159764 hasExactSynonym "REGN 4659" @default.
- NCIT_C159764 hasExactSynonym "REGN-4659" @default.
- NCIT_C159764 hasExactSynonym "REGN4659" @default.
- NCIT_C159764 inSubset NCIT_C116977 @default.
- NCIT_C159764 inSubset NCIT_C116978 @default.
- NCIT_C159764 inSubset NCIT_C128784 @default.
- NCIT_C159764 inSubset NCIT_C157711 @default.
- NCIT_C159764 inSubset NCIT_C157712 @default.
- NCIT_C159764 inSubset NCIT_C176424 @default.
- NCIT_C159764 inSubset NCIT_C177537 @default.
- NCIT_C159764 inSubset NCIT_C63923 @default.
- NCIT_C159764 type Class @default.
- NCIT_C159764 isDefinedBy ncit.owl @default.
- NCIT_C159764 label "Anti-CTLA-4 Monoclonal Antibody REGN4659" @default.
- NCIT_C159764 subClassOf NCIT_C128036 @default.
- NCIT_C159764 subClassOf NCIT_C129821 @default.
- NCIT_C159764 subClassOf NCIT_C129822 @default.
- NCIT_C159764 subClassOf NCIT_C141144 @default.
- NCIT_C159764 subClassOf NCIT_C143250 @default.
- NCIT_C159764 subClassOf NCIT_C159764 @default.
- NCIT_C159764 subClassOf NCIT_C163758 @default.
- NCIT_C159764 subClassOf NCIT_C1908 @default.
- NCIT_C159764 subClassOf NCIT_C1909 @default.
- NCIT_C159764 subClassOf NCIT_C191738 @default.
- NCIT_C159764 subClassOf NCIT_C20401 @default.
- NCIT_C159764 subClassOf NCIT_C274 @default.
- NCIT_C159764 subClassOf NCIT_C307 @default.
- NCIT_C159764 subClassOf NCIT_C308 @default.