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- NCIT_C159888 IAO_0000115 "An extended-release (ER) formulation of the hydrobromide salt form of galantamine, a tertiary alkaloid obtained synthetically or naturally from the bulbs and flowers of Narcissus and several other genera of the Amaryllidaceae family, with anticholinesterase and neurocognitive-enhancing activities. Upon administration, galantamine competitively and reversibly inhibits acetylcholinesterase, thereby increasing the concentration and enhancing the action of acetylcholine (Ach). In addition, galantamine is a ligand for nicotinic acetylcholine receptors, which may increase the presynaptic release of Ach and activate postsynaptic receptors. This agent may improve neurocognitive function in mild and moderate Alzheimer's disease and may, through its Ach stimulating effect on nicotinic receptors, help quit smoking and reduce abstinence-induced cognitive symptoms that promote smoking relapse." @default.
- NCIT_C159888 NCIT_A6 NCIT_C65797 @default.
- NCIT_C159888 NCIT_A7 NCIT_C201243 @default.
- NCIT_C159888 NCIT_NHC0 "C159888" @default.
- NCIT_C159888 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C159888 NCIT_P107 "Extended-release Galantamine Hydrobromide" @default.
- NCIT_C159888 NCIT_P108 "Extended-release Galantamine Hydrobromide" @default.
- NCIT_C159888 NCIT_P208 "CL968962" @default.
- NCIT_C159888 NCIT_P322 "CTRP" @default.
- NCIT_C159888 NCIT_P329 "797963" @default.
- NCIT_C159888 NCIT_P330 "797963" @default.
- NCIT_C159888 NCIT_P366 "Galantamine_Hydrobromide" @default.
- NCIT_C159888 NCIT_P399 "797963" @default.
- NCIT_C159888 normalizedInformationContent "100" @default.
- NCIT_C159888 referenceCount "1" @default.
- NCIT_C159888 hasExactSynonym "ER Galantamine Hydrobromide" @default.
- NCIT_C159888 hasExactSynonym "Extended-release Galantamine Hydrobromide" @default.
- NCIT_C159888 hasExactSynonym "Galantamine Hydrobromide ER" @default.
- NCIT_C159888 hasExactSynonym "Galantamine Hydrobromide Extended Release" @default.
- NCIT_C159888 hasExactSynonym "Lycoremine Hydrobromide ER" @default.
- NCIT_C159888 hasExactSynonym "Razadyne ER" @default.
- NCIT_C159888 inSubset NCIT_C116977 @default.
- NCIT_C159888 inSubset NCIT_C116978 @default.
- NCIT_C159888 inSubset NCIT_C176424 @default.
- NCIT_C159888 type Class @default.
- NCIT_C159888 isDefinedBy ncit.owl @default.
- NCIT_C159888 label "Extended-release Galantamine Hydrobromide" @default.
- NCIT_C159888 subClassOf NCIT_C159888 @default.
- NCIT_C159888 subClassOf NCIT_C1908 @default.
- NCIT_C159888 subClassOf NCIT_C1909 @default.
- NCIT_C159888 subClassOf NCIT_C471 @default.
- NCIT_C159888 subClassOf NCIT_C47792 @default.