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- NCIT_C159940 IAO_0000115 "A preparation of allogeneic peripheral blood stem cells (PBSCs) from an unrelated or partially matched related donor that have been selectively depleted of alpha/beta T-cells and CD19-positive (CD19+) B-cells with potential immune reconstituting activity. The alpha/beta T-cell/CD19+ B-cell-depleted stem cells contain high amounts of natural killer (NK) cells, gamma/delta T-cells, CD34+ stem cells, and dendritic cells (DCs), while devoid of alpha/beta T-cells and CD19-positive B-cells. Depletion of alpha/beta T-cells, which are implicated in the adaptive immune response that mediates graft-versus-host disease (GvHD), may promote rapid and sustained engraftment, immune reconstitution, and may prevent or reduce the development of GvHD. The depletion of CD19+ B-cells may reduce the risk of Epstein-Barr virus (EBV)-driven post-transplant lymphoproliferative disorders. The retained CD3+ gamma/delta T-cells and NK cells may synergistically exert an anti-leukemic and antiviral effector function, which may further promote engraftment and immune reconstitution." @default.
- NCIT_C159940 NCIT_NHC0 "C159940" @default.
- NCIT_C159940 NCIT_P106 "Cell" @default.
- NCIT_C159940 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C159940 NCIT_P107 "Alpha/beta T-cell/CD19+ B-cell-depleted Unrelated or Partially Matched Donor-derived Allogeneic Peripheral Blood Stem Cells" @default.
- NCIT_C159940 NCIT_P108 "Alpha/beta T-cell/CD19+ B-cell-depleted Unrelated or Partially Matched Donor-derived Allogeneic Peripheral Blood Stem Cells" @default.
- NCIT_C159940 NCIT_P208 "CL969107" @default.
- NCIT_C159940 NCIT_P322 "CTRP" @default.
- NCIT_C159940 NCIT_P329 "797965" @default.
- NCIT_C159940 NCIT_P330 "797965" @default.
- NCIT_C159940 NCIT_P399 "797965" @default.
- NCIT_C159940 normalizedInformationContent "100" @default.
- NCIT_C159940 referenceCount "1" @default.
- NCIT_C159940 hasExactSynonym "Alpha/beta T-cell and CD19+ B-cell-depleted Allogeneic PBSCs Derived from an Unrelated or Partially Matched Donor" @default.
- NCIT_C159940 hasExactSynonym "Alpha/beta T-cell/CD19+ B-cell-depleted Unrelated or Partially Matched Donor-derived Allogeneic PBSCs" @default.
- NCIT_C159940 hasExactSynonym "Alpha/beta T-cell/CD19+ B-cell-depleted Unrelated or Partially Matched Donor-derived Allogeneic Peripheral Blood Stem Cells" @default.
- NCIT_C159940 inSubset NCIT_C116977 @default.
- NCIT_C159940 inSubset NCIT_C116978 @default.
- NCIT_C159940 inSubset NCIT_C176424 @default.
- NCIT_C159940 type Class @default.
- NCIT_C159940 isDefinedBy ncit.owl @default.
- NCIT_C159940 label "Alpha/beta T-cell/CD19+ B-cell-depleted Unrelated or Partially Matched Donor-derived Allogeneic Peripheral Blood Stem Cells" @default.
- NCIT_C159940 subClassOf NCIT_C142078 @default.
- NCIT_C159940 subClassOf NCIT_C159940 @default.
- NCIT_C159940 subClassOf NCIT_C1908 @default.
- NCIT_C159940 subClassOf NCIT_C1909 @default.
- NCIT_C159940 subClassOf NCIT_C201557 @default.
- NCIT_C159940 subClassOf NCIT_C307 @default.
- NCIT_C159940 subClassOf NCIT_C308 @default.