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- NCIT_C159943 IAO_0000115 "The besylate salt of molibresib, a small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic activity. Upon administration, molibresib binds to the acetylated lysine recognition motifs on the bromodomain of BET proteins, thereby preventing the interaction between the BET proteins and acetylated histone peptides. This disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of bromodomain at the N-terminus, BET proteins, comprising of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during development and cellular growth." @default.
- NCIT_C159943 NCIT_A32 NCIT_C1909 @default.
- NCIT_C159943 NCIT_A6 NCIT_C101538 @default.
- NCIT_C159943 NCIT_A7 NCIT_C106463 @default.
- NCIT_C159943 NCIT_A7 NCIT_C21376 @default.
- NCIT_C159943 NCIT_A7 NCIT_C92704 @default.
- NCIT_C159943 NCIT_A7 NCIT_C97399 @default.
- NCIT_C159943 NCIT_NHC0 "C159943" @default.
- NCIT_C159943 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C159943 NCIT_P107 "Molibresib Besylate" @default.
- NCIT_C159943 NCIT_P108 "Molibresib Besylate" @default.
- NCIT_C159943 NCIT_P208 "CL969105" @default.
- NCIT_C159943 NCIT_P210 "1895049-20-3" @default.
- NCIT_C159943 NCIT_P319 "K04D7I4BCH" @default.
- NCIT_C159943 NCIT_P322 "CTRP" @default.
- NCIT_C159943 NCIT_P322 "FDA" @default.
- NCIT_C159943 NCIT_P322 "GDC" @default.
- NCIT_C159943 NCIT_P329 "801626" @default.
- NCIT_C159943 NCIT_P330 "801626" @default.
- NCIT_C159943 NCIT_P375 "Molibresib Besylate" @default.
- NCIT_C159943 NCIT_P399 "801626" @default.
- NCIT_C159943 normalizedInformationContent "100" @default.
- NCIT_C159943 referenceCount "1" @default.
- NCIT_C159943 hasExactSynonym "2-((4S)-6-(4-Chlorophenyl)-8-methoxy-1-methyl-4H-(1,2,4)triazolo(4,3-a)(1,4)benzodiazepin-4-yl)-N-ethylacetamide monobenzenesulfonate salt" @default.
- NCIT_C159943 hasExactSynonym "GSK525762C" @default.
- NCIT_C159943 hasExactSynonym "MOLIBRESIB BESYLATE" @default.
- NCIT_C159943 hasExactSynonym "Molibresib Besylate" @default.
- NCIT_C159943 inSubset NCIT_C116977 @default.
- NCIT_C159943 inSubset NCIT_C116978 @default.
- NCIT_C159943 inSubset NCIT_C128784 @default.
- NCIT_C159943 inSubset NCIT_C157711 @default.
- NCIT_C159943 inSubset NCIT_C157712 @default.
- NCIT_C159943 inSubset NCIT_C176424 @default.
- NCIT_C159943 inSubset NCIT_C177537 @default.
- NCIT_C159943 inSubset NCIT_C63923 @default.
- NCIT_C159943 type Class @default.
- NCIT_C159943 isDefinedBy ncit.owl @default.
- NCIT_C159943 label "Molibresib Besylate" @default.
- NCIT_C159943 subClassOf NCIT_C128462 @default.
- NCIT_C159943 subClassOf NCIT_C129824 @default.
- NCIT_C159943 subClassOf NCIT_C159943 @default.
- NCIT_C159943 subClassOf NCIT_C1908 @default.
- NCIT_C159943 subClassOf NCIT_C1909 @default.
- NCIT_C159943 subClassOf NCIT_C2189 @default.
- NCIT_C159943 subClassOf NCIT_C274 @default.