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- NCIT_C159973 IAO_0000115 "A fixed dose combination of elbasvir, an inhibitor of the hepatitis C virus (HCV) non-structural protein 5A (NS5A), and grazoprevir, a second-generation inhibitor of the HCV NS3/4A serine protease, with activity against certain HCV genotypes. Upon oral administration of elbasvir/grazoprevir, elbasvir inhibits the activity of the NS5A protein, leading to disruption of the viral RNA replication complex, blockage of HCV RNA production, and inhibition of viral replication. Grazoprevir inhibits the NS3/4A serine protease enzyme, thereby disrupting the cleavage of the virally encoded polyprotein into mature proteins and preventing the formation of the viral replication complex. HCV is a small, enveloped, single-stranded RNA virus belonging to the Flaviviridae family; HCV infection is associated with the development of certain cancers." @default.
- NCIT_C159973 NCIT_A32 NCIT_C1909 @default.
- NCIT_C159973 NCIT_NHC0 "C159973" @default.
- NCIT_C159973 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C159973 NCIT_P107 "Elbasvir/Grazoprevir" @default.
- NCIT_C159973 NCIT_P108 "Elbasvir/Grazoprevir" @default.
- NCIT_C159973 NCIT_P207 "C4080453" @default.
- NCIT_C159973 NCIT_P322 "CTRP" @default.
- NCIT_C159973 NCIT_P322 "GDC" @default.
- NCIT_C159973 NCIT_P329 "797922" @default.
- NCIT_C159973 NCIT_P330 "797922" @default.
- NCIT_C159973 NCIT_P375 "Elbasvir/Grazoprevir" @default.
- NCIT_C159973 NCIT_P399 "797922" @default.
- NCIT_C159973 normalizedInformationContent "100" @default.
- NCIT_C159973 referenceCount "1" @default.
- NCIT_C159973 hasExactSynonym "Elbasvir-Grazoprevir" @default.
- NCIT_C159973 hasExactSynonym "Elbasvir/Grazoprevir" @default.
- NCIT_C159973 hasExactSynonym "Grazoprevir-Elbasvir" @default.
- NCIT_C159973 hasExactSynonym "Grazoprevir/Elbasvir" @default.
- NCIT_C159973 hasExactSynonym "MK-8742/ MK-5172" @default.
- NCIT_C159973 hasExactSynonym "Zepatier" @default.
- NCIT_C159973 inSubset NCIT_C116977 @default.
- NCIT_C159973 inSubset NCIT_C116978 @default.
- NCIT_C159973 inSubset NCIT_C157711 @default.
- NCIT_C159973 inSubset NCIT_C157712 @default.
- NCIT_C159973 inSubset NCIT_C176424 @default.
- NCIT_C159973 inSubset NCIT_C177537 @default.
- NCIT_C159973 type Class @default.
- NCIT_C159973 isDefinedBy ncit.owl @default.
- NCIT_C159973 label "Elbasvir/Grazoprevir" @default.
- NCIT_C159973 subClassOf NCIT_C159973 @default.
- NCIT_C159973 subClassOf NCIT_C1908 @default.
- NCIT_C159973 subClassOf NCIT_C1909 @default.
- NCIT_C159973 subClassOf NCIT_C254 @default.
- NCIT_C159973 subClassOf NCIT_C281 @default.
- NCIT_C159973 subClassOf NCIT_C471 @default.
- NCIT_C159973 subClassOf NCIT_C783 @default.