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- NCIT_C160147 IAO_0000115 "An orally bioavailable inhibitor of mucosa-associated lymphoid tissue lymphoma translocation protein 1 (MALT1), with potential antineoplastic activity. Upon administration, safimaltib targets, binds to, and prevents the activity of MALT1. This inhibits MALT1-dependent signaling, reduces interleukin-10 (IL-10) and upregulates interferon (IFN). This results in the inhibition of Janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling and nuclear factor-kappa B (NF-kB) signaling, induces apoptosis, and inhibits tumor cell growth of MALT1-expressing tumor cells. MALT1 belongs to the caspase family of proteases and is the active component of the CARD11-BCL10-MALT1 (CBM) signaling complex. It plays an essential role in B- and T-lymphocyte activation and is over-activated in certain tumor cells." @default.
- NCIT_C160147 NCIT_A32 NCIT_C1909 @default.
- NCIT_C160147 NCIT_A7 NCIT_C60673 @default.
- NCIT_C160147 NCIT_NHC0 "C160147" @default.
- NCIT_C160147 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C160147 NCIT_P107 "Safimaltib" @default.
- NCIT_C160147 NCIT_P108 "Safimaltib" @default.
- NCIT_C160147 NCIT_P208 "CL969161" @default.
- NCIT_C160147 NCIT_P210 "2230273-76-2" @default.
- NCIT_C160147 NCIT_P319 "L9790S42AI" @default.
- NCIT_C160147 NCIT_P322 "CTRP" @default.
- NCIT_C160147 NCIT_P322 "FDA" @default.
- NCIT_C160147 NCIT_P322 "GDC" @default.
- NCIT_C160147 NCIT_P329 "798315" @default.
- NCIT_C160147 NCIT_P330 "798315" @default.
- NCIT_C160147 NCIT_P375 "MALT1 Inhibitor JNJ-67856633" @default.
- NCIT_C160147 NCIT_P399 "798315" @default.
- NCIT_C160147 normalizedInformationContent "100" @default.
- NCIT_C160147 referenceCount "1" @default.
- NCIT_C160147 hasExactSynonym "1-(1-Oxo-1,2-dihydroisoquinolin-5-yl)-5-(trifluoromethyl)-N-(2-(trifluoromethyl)pyridin-4-yl)-1H-pyrazole-4-carboxamide" @default.
- NCIT_C160147 hasExactSynonym "JNJ 67856633" @default.
- NCIT_C160147 hasExactSynonym "JNJ-67856633" @default.
- NCIT_C160147 hasExactSynonym "JNJ67856633" @default.
- NCIT_C160147 hasExactSynonym "MALT1 Inhibitor JNJ-67856633" @default.
- NCIT_C160147 hasExactSynonym "Mucosa-associated Lymphoid Tissue Lymphoma Translocation Protein 1 Inhibitor JNJ-67856633" @default.
- NCIT_C160147 hasExactSynonym "SAFIMALTIB" @default.
- NCIT_C160147 hasExactSynonym "Safimaltib" @default.
- NCIT_C160147 inSubset NCIT_C116977 @default.
- NCIT_C160147 inSubset NCIT_C116978 @default.
- NCIT_C160147 inSubset NCIT_C128784 @default.
- NCIT_C160147 inSubset NCIT_C157711 @default.
- NCIT_C160147 inSubset NCIT_C157712 @default.
- NCIT_C160147 inSubset NCIT_C176424 @default.
- NCIT_C160147 inSubset NCIT_C177537 @default.
- NCIT_C160147 inSubset NCIT_C63923 @default.
- NCIT_C160147 type Class @default.
- NCIT_C160147 isDefinedBy ncit.owl @default.
- NCIT_C160147 label "Safimaltib" @default.
- NCIT_C160147 subClassOf NCIT_C129824 @default.
- NCIT_C160147 subClassOf NCIT_C129825 @default.
- NCIT_C160147 subClassOf NCIT_C160147 @default.
- NCIT_C160147 subClassOf NCIT_C1908 @default.
- NCIT_C160147 subClassOf NCIT_C1909 @default.
- NCIT_C160147 subClassOf NCIT_C2189 @default.
- NCIT_C160147 subClassOf NCIT_C274 @default.
- NCIT_C160147 subClassOf NCIT_C471 @default.