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- NCIT_C160192 IAO_0000115 "A selectively replication competent oncolytic adenovirus that is engineered to express OX40 ligand (OX40L) with potential oncolytic and immunostimulatory activities. Upon administration, tezemlimogene daxadenorepvec, which contains an integrin binding RGD-4C motif, infects tumor cells in a Coxsackievirus-adenovirus receptor-independent manner and selectively replicates in tumor cells that are defective in retinoblastoma gene (Rb) or cyclin-dependent kinase inhibitor-2A (p16). Tumor cell selectivity is achieved through a 24-base pair deletion in the E1A gene, which renders the oncolytic adenovirus unable to replicate in normal cells that maintain a functional Rb pathway, but fully replication competent in Rb/p16 defective tumor cells. Active replication of the OX40L-expressing oncolytic adenovirus within tumor cells may induce oncolysis and release of OX40L. OX40L may then bind to and activate signaling pathways downstream of its cognate receptor, tumor necrosis factor receptor superfamily member 4 (TNFRSF4; OX40), which is expressed on activated T-cells. OX40L/OX40 binding promotes increased cytokine production, which can induce proliferation of memory and effector T-lymphocytes and promote the killing of nearby tumor cells. OX40L, a cell surface glycoprotein and member of the tumor necrosis factor (TNF) ligand family, provides a co-stimulatory signal for the proliferation and survival of activated T-cells. The Rb gene product and p16 are negative regulators of the cell cycle and are defective in certain tumor types." @default.
- NCIT_C160192 NCIT_A32 NCIT_C1909 @default.
- NCIT_C160192 NCIT_NHC0 "C160192" @default.
- NCIT_C160192 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C160192 NCIT_P107 "Tezemlimogene Daxadenorepvec" @default.
- NCIT_C160192 NCIT_P108 "Tezemlimogene Daxadenorepvec" @default.
- NCIT_C160192 NCIT_P208 "CL969332" @default.
- NCIT_C160192 NCIT_P210 "2642046-11-3" @default.
- NCIT_C160192 NCIT_P319 "B7N7BR6M4A" @default.
- NCIT_C160192 NCIT_P322 "CTRP" @default.
- NCIT_C160192 NCIT_P322 "FDA" @default.
- NCIT_C160192 NCIT_P322 "GDC" @default.
- NCIT_C160192 NCIT_P329 "797863" @default.
- NCIT_C160192 NCIT_P330 "797863" @default.
- NCIT_C160192 NCIT_P375 "OX40L-expressing Oncolytic Adenovirus DNX-2440" @default.
- NCIT_C160192 NCIT_P399 "797863" @default.
- NCIT_C160192 normalizedInformationContent "100" @default.
- NCIT_C160192 referenceCount "1" @default.
- NCIT_C160192 hasExactSynonym "DNX 2440" @default.
- NCIT_C160192 hasExactSynonym "DNX-2440" @default.
- NCIT_C160192 hasExactSynonym "DNX2440" @default.
- NCIT_C160192 hasExactSynonym "OX40L-expressing Oncolytic Adenovirus DNX-2440" @default.
- NCIT_C160192 hasExactSynonym "Oncolytic Adenovirus Armed With OX40L DNX-2440" @default.
- NCIT_C160192 hasExactSynonym "TEZEMLIMOGENE DAXADENOREPVEC" @default.
- NCIT_C160192 hasExactSynonym "Tezemlimogene Daxadenorepvec" @default.
- NCIT_C160192 inSubset NCIT_C116977 @default.
- NCIT_C160192 inSubset NCIT_C116978 @default.
- NCIT_C160192 inSubset NCIT_C128784 @default.
- NCIT_C160192 inSubset NCIT_C157711 @default.
- NCIT_C160192 inSubset NCIT_C157712 @default.
- NCIT_C160192 inSubset NCIT_C176424 @default.
- NCIT_C160192 inSubset NCIT_C177537 @default.
- NCIT_C160192 inSubset NCIT_C63923 @default.
- NCIT_C160192 type Class @default.
- NCIT_C160192 isDefinedBy ncit.owl @default.
- NCIT_C160192 label "Tezemlimogene Daxadenorepvec" @default.
- NCIT_C160192 subClassOf NCIT_C129821 @default.
- NCIT_C160192 subClassOf NCIT_C160192 @default.
- NCIT_C160192 subClassOf NCIT_C1908 @default.
- NCIT_C160192 subClassOf NCIT_C1909 @default.
- NCIT_C160192 subClassOf NCIT_C274 @default.
- NCIT_C160192 subClassOf NCIT_C307 @default.
- NCIT_C160192 subClassOf NCIT_C717 @default.