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- NCIT_C160257 IAO_0000115 "An orally bioavailable inhibitor of the bromodomain and extra-terminal (BET) family of proteins with potential antineoplastic activity. Upon oral administration, amredobresib binds to bromodomain-containing proteins 2, 3, and 4 (BRD2, BRD3, and BRD4) as well as bromodomain testis-specific protein (BRDT), thereby preventing the interaction between BET proteins and acetylated histones. This disrupts chromatin remodeling and suppresses the expression of certain oncogenes, including Myc and other transcriptional regulators. Preventing the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of bromodomains at the N-terminus, BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during cellular development and growth." @default.
- NCIT_C160257 NCIT_A32 NCIT_C1909 @default.
- NCIT_C160257 NCIT_A7 NCIT_C106463 @default.
- NCIT_C160257 NCIT_A7 NCIT_C21376 @default.
- NCIT_C160257 NCIT_A7 NCIT_C92704 @default.
- NCIT_C160257 NCIT_A7 NCIT_C97399 @default.
- NCIT_C160257 NCIT_NHC0 "C160257" @default.
- NCIT_C160257 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C160257 NCIT_P107 "Amredobresib" @default.
- NCIT_C160257 NCIT_P108 "Amredobresib" @default.
- NCIT_C160257 NCIT_P208 "CL969271" @default.
- NCIT_C160257 NCIT_P210 "1610044-98-8" @default.
- NCIT_C160257 NCIT_P319 "F6XR3O34V2" @default.
- NCIT_C160257 NCIT_P322 "CTRP" @default.
- NCIT_C160257 NCIT_P322 "FDA" @default.
- NCIT_C160257 NCIT_P322 "GDC" @default.
- NCIT_C160257 NCIT_P375 "BET inhibitor BI 894999" @default.
- NCIT_C160257 normalizedInformationContent "100" @default.
- NCIT_C160257 referenceCount "1" @default.
- NCIT_C160257 hasExactSynonym "1,2,4-Triazolo(4,3-a)pyrazin-8-amine, N,3-dimethyl-6-(6-(4-methyl-1-piperazinyl)-1-(phenylmethyl)-1hbenzimidazol-2-yl)" @default.
- NCIT_C160257 hasExactSynonym "6-(1-Benzyl-6-(4-methylpiperazin-1-yl)-1H-1,3-benzodiazol-2-yl)-N,3-dimethyl-(1,2,4)triazolo(4,3-a)pyrazin-8-amine" @default.
- NCIT_C160257 hasExactSynonym "AMREDOBRESIB" @default.
- NCIT_C160257 hasExactSynonym "Amredobresib" @default.
- NCIT_C160257 hasExactSynonym "BET inhibitor BI 894999" @default.
- NCIT_C160257 hasExactSynonym "BI 894999" @default.
- NCIT_C160257 hasExactSynonym "BI-894999" @default.
- NCIT_C160257 hasExactSynonym "BI894999" @default.
- NCIT_C160257 inSubset NCIT_C116977 @default.
- NCIT_C160257 inSubset NCIT_C116978 @default.
- NCIT_C160257 inSubset NCIT_C128784 @default.
- NCIT_C160257 inSubset NCIT_C157711 @default.
- NCIT_C160257 inSubset NCIT_C157712 @default.
- NCIT_C160257 inSubset NCIT_C177537 @default.
- NCIT_C160257 inSubset NCIT_C63923 @default.
- NCIT_C160257 type Class @default.
- NCIT_C160257 isDefinedBy ncit.owl @default.
- NCIT_C160257 label "Amredobresib" @default.
- NCIT_C160257 subClassOf NCIT_C128462 @default.
- NCIT_C160257 subClassOf NCIT_C129824 @default.
- NCIT_C160257 subClassOf NCIT_C160257 @default.
- NCIT_C160257 subClassOf NCIT_C1908 @default.
- NCIT_C160257 subClassOf NCIT_C1909 @default.
- NCIT_C160257 subClassOf NCIT_C2189 @default.
- NCIT_C160257 subClassOf NCIT_C274 @default.