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- NCIT_C160606 IAO_0000115 "The besylate form of bocodepsin, an orally bioavailable inhibitor of the histone deacetylase (HDAC) subtypes 1 and 4, with potential antineoplastic activity. Upon administration,bocodepsin targets, binds to and inhibits the activity of HDAC1/4. This results in an accumulation of highly acetylated chromatin histones, the induction of chromatin remodeling and an altered pattern of gene expression. This consequently results in a selective transcription of tumor suppressor genes, tumor suppressor protein-mediated inhibition of tumor cell division and an induction of apoptosis in tumor cells that overexpress HDAC1/4. HDAC, which is upregulated in many tumor cell types, deacetylates chromatin histone proteins and plays a key role in transcriptional regulation and cell cycle progression." @default.
- NCIT_C160606 NCIT_A32 NCIT_C1909 @default.
- NCIT_C160606 NCIT_A7 NCIT_C16682 @default.
- NCIT_C160606 NCIT_NHC0 "C160606" @default.
- NCIT_C160606 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C160606 NCIT_P107 "Bocodepsin Besylate" @default.
- NCIT_C160606 NCIT_P108 "Bocodepsin Besylate" @default.
- NCIT_C160606 NCIT_P208 "CL969661" @default.
- NCIT_C160606 NCIT_P210 "1834513-67-5" @default.
- NCIT_C160606 NCIT_P319 "LVM50TS2UO" @default.
- NCIT_C160606 NCIT_P322 "CTRP" @default.
- NCIT_C160606 NCIT_P322 "FDA" @default.
- NCIT_C160606 NCIT_P322 "GDC" @default.
- NCIT_C160606 NCIT_P329 "801634" @default.
- NCIT_C160606 NCIT_P330 "801634" @default.
- NCIT_C160606 NCIT_P375 "Class 1/4 Histone Deacetylase Inhibitor OKI-179" @default.
- NCIT_C160606 NCIT_P399 "801634" @default.
- NCIT_C160606 normalizedInformationContent "100" @default.
- NCIT_C160606 referenceCount "1" @default.
- NCIT_C160606 hasExactSynonym "BOCODEPSIN BESYLATE" @default.
- NCIT_C160606 hasExactSynonym "Bocodepsin Besylate" @default.
- NCIT_C160606 hasExactSynonym "Class 1/4 Histone Deacetylase Inhibitor OKI-179" @default.
- NCIT_C160606 hasExactSynonym "Class-1/4 HDACi OKI-179" @default.
- NCIT_C160606 hasExactSynonym "HDAC Inhibitor OKI-179" @default.
- NCIT_C160606 hasExactSynonym "HDAC1/4i OKI-179" @default.
- NCIT_C160606 hasExactSynonym "HDACi 1/4 OKI-179" @default.
- NCIT_C160606 hasExactSynonym "HDACi OKI-179" @default.
- NCIT_C160606 hasExactSynonym "OKI 179" @default.
- NCIT_C160606 hasExactSynonym "OKI-179" @default.
- NCIT_C160606 hasExactSynonym "OKI179" @default.
- NCIT_C160606 inSubset NCIT_C116977 @default.
- NCIT_C160606 inSubset NCIT_C116978 @default.
- NCIT_C160606 inSubset NCIT_C128784 @default.
- NCIT_C160606 inSubset NCIT_C157711 @default.
- NCIT_C160606 inSubset NCIT_C157712 @default.
- NCIT_C160606 inSubset NCIT_C176424 @default.
- NCIT_C160606 inSubset NCIT_C177537 @default.
- NCIT_C160606 inSubset NCIT_C63923 @default.
- NCIT_C160606 type Class @default.
- NCIT_C160606 isDefinedBy ncit.owl @default.
- NCIT_C160606 label "Bocodepsin Besylate" @default.
- NCIT_C160606 subClassOf NCIT_C129824 @default.
- NCIT_C160606 subClassOf NCIT_C129825 @default.
- NCIT_C160606 subClassOf NCIT_C160606 @default.
- NCIT_C160606 subClassOf NCIT_C163758 @default.
- NCIT_C160606 subClassOf NCIT_C1908 @default.
- NCIT_C160606 subClassOf NCIT_C1909 @default.
- NCIT_C160606 subClassOf NCIT_C1946 @default.
- NCIT_C160606 subClassOf NCIT_C2189 @default.
- NCIT_C160606 subClassOf NCIT_C274 @default.
- NCIT_C160606 subClassOf NCIT_C471 @default.