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- NCIT_C1607 IAO_0000115 "A nonsteroidal inhibitor of estrogen synthesis that resembles paclitaxel in chemical structure. As a third-generation aromatase inhibitor, anastrozole selectively binds to and reversibly inhibits aromatase, a cytochrome P-450 enzyme complex found in many tissues including those of the premenopausal ovary, liver, and breast; aromatase catalyzes the aromatization of androstenedione and testosterone into estrone and estradiol, the final step in estrogen biosynthesis. In estrogen-dependent breast cancers, ananstrozole may inhibit tumor growth. (NCI04)" @default.
- NCIT_C1607 NCIT_A32 NCIT_C1909 @default.
- NCIT_C1607 NCIT_A7 NCIT_C16307 @default.
- NCIT_C1607 NCIT_NHC0 "C1607" @default.
- NCIT_C1607 NCIT_P106 "Organic Chemical" @default.
- NCIT_C1607 NCIT_P106 "Pharmacologic Substance" @default.
- NCIT_C1607 NCIT_P107 "Anastrozole" @default.
- NCIT_C1607 NCIT_P108 "Anastrozole" @default.
- NCIT_C1607 NCIT_P175 "719344" @default.
- NCIT_C1607 NCIT_P207 "C0290883" @default.
- NCIT_C1607 NCIT_P210 "120511-73-1" @default.
- NCIT_C1607 NCIT_P302 "Hormone Receptor-Positive Early Breast cancer" @default.
- NCIT_C1607 NCIT_P319 "2Z07MYW1AZ" @default.
- NCIT_C1607 NCIT_P322 "CTRP" @default.
- NCIT_C1607 NCIT_P322 "FDA" @default.
- NCIT_C1607 NCIT_P322 "GDC" @default.
- NCIT_C1607 NCIT_P325 "An anticancer drug that is used to decrease estrogen production and suppress the growth of tumors that need estrogen to grow. It is a type of nonsteroidal aromatase inhibitor." @default.
- NCIT_C1607 NCIT_P329 "42540" @default.
- NCIT_C1607 NCIT_P330 "42540" @default.
- NCIT_C1607 NCIT_P350 "C17H19N5" @default.
- NCIT_C1607 NCIT_P366 "Anastrozole" @default.
- NCIT_C1607 NCIT_P368 "CHEBI:2704" @default.
- NCIT_C1607 NCIT_P375 "Anastrozole" @default.
- NCIT_C1607 NCIT_P399 "42540" @default.
- NCIT_C1607 normalizedInformationContent "83.027314241919257" @default.
- NCIT_C1607 referenceCount "13" @default.
- NCIT_C1607 hasExactSynonym "2,2'-[5-(1H-1,2,4-Triazol-1-ylmethyl)-1,3-phenylene]di(2-methylpropionitrile)" @default.
- NCIT_C1607 hasExactSynonym "ANASTROZOLE" @default.
- NCIT_C1607 hasExactSynonym "Alpha,alpha,alpha', alpha'-tetramethyl-5-(1H-1,2,4-triazol-1-ylmethyl)-1,3-benzenediacetonitrile" @default.
- NCIT_C1607 hasExactSynonym "Anastrazole" @default.
- NCIT_C1607 hasExactSynonym "Anastrozole" @default.
- NCIT_C1607 hasExactSynonym "Arimidex" @default.
- NCIT_C1607 hasExactSynonym "ICI D1033" @default.
- NCIT_C1607 hasExactSynonym "ICI-D1033" @default.
- NCIT_C1607 hasExactSynonym "ZD-1033" @default.
- NCIT_C1607 hasExactSynonym "anastrozole" @default.
- NCIT_C1607 inSubset NCIT_C116977 @default.
- NCIT_C1607 inSubset NCIT_C116978 @default.
- NCIT_C1607 inSubset NCIT_C128784 @default.
- NCIT_C1607 inSubset NCIT_C157711 @default.
- NCIT_C1607 inSubset NCIT_C157712 @default.
- NCIT_C1607 inSubset NCIT_C176424 @default.
- NCIT_C1607 inSubset NCIT_C177537 @default.
- NCIT_C1607 inSubset NCIT_C63923 @default.
- NCIT_C1607 type Class @default.
- NCIT_C1607 isDefinedBy ncit.owl @default.
- NCIT_C1607 label "Anastrozole" @default.
- NCIT_C1607 subClassOf NCIT_C129818 @default.
- NCIT_C1607 subClassOf NCIT_C129824 @default.
- NCIT_C1607 subClassOf NCIT_C129825 @default.
- NCIT_C1607 subClassOf NCIT_C147908 @default.
- NCIT_C1607 subClassOf NCIT_C1607 @default.
- NCIT_C1607 subClassOf NCIT_C163758 @default.
- NCIT_C1607 subClassOf NCIT_C1740 @default.
- NCIT_C1607 subClassOf NCIT_C1908 @default.
- NCIT_C1607 subClassOf NCIT_C1909 @default.
- NCIT_C1607 subClassOf NCIT_C2018 @default.
- NCIT_C1607 subClassOf NCIT_C2189 @default.
- NCIT_C1607 subClassOf NCIT_C274 @default.
- NCIT_C1607 subClassOf NCIT_C471 @default.
- NCIT_C1607 subClassOf NCIT_C481 @default.
- NCIT_C1607 subClassOf NCIT_C547 @default.